4046-02-0

4046-02-0 structure

Name: Ethyl ferulate
Chemical Name: Ethyl 4'-hydroxy-3'-methoxycinnamate
CAS Number: 4046-02-0
Molecular Formula: C₁₂H₁₄O₄
Molecular Weight: 222.24
Catalog: Chemical reagent Organic reagent Ester Ethyl ester compound
Create Date: 2018-04-07 08:00:00
Modify Date: 2024-01-02 22:13:07
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from giant fennel (F. communis), induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity[2].

Name	Ethyl 4'-hydroxy-3'-methoxycinnamate
Synonyms	ethyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate MFCD00009190 4-Hydroxy-3-methoxycinnamic Acid Ethyl Ester Ferulic acid ethyl ester Ethyl 4-Hydroxy-3-MethoxycinnaMate 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-, ethyl ester EINECS 223-745-5 Ethyl Ferulate Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Description	Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from giant fennel (F. communis), induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress[1]. Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity[2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Scapagnini G, et al. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal. 2004 Oct;6(5):811-8. [2]. Sultana R, et al. Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity. J Neurochem. 2005 Feb;92(4):749-58.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2918990090

1135-24-6

64-17-5

~93%

4046-02-0

Literature: Molecules, , vol. 14, # 6 p. 2118 - 2126

6635-27-4

~96%

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Literature: Tetrahedron, , vol. 59, # 7 p. 1049 - 1054

121-33-5

1099-45-2

~82%

4046-02-0

Literature: Organic Letters, , vol. 14, # 15 p. 3902 - 3905

97-54-1

140-88-5

~92%

4046-02-0

Literature: Journal of the American Chemical Society, , vol. 134, # 46 p. 18889 - 18891

121-33-5

4046-02-0

Literature: Tetrahedron, , vol. 57, # 2 p. 365 - 370

121-33-5

1099-45-2

4046-02-0

Literature: Liebigs Annalen der Chemie, , # 12 p. 2135 - 2140

1071-46-1

121-33-5

4046-02-0

Literature: Chemische Berichte, , vol. 85, p. 1181,1188

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%