Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ferulic acid
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: ferulic acid
Price: ￥108.0/25g ￥318.0/100g ￥258.0/20mg
Purity: 99.0%
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Contact: Liu jia

DC Chemicals Limited
China
Product Name: Fumalic acid (Ferulic acid)
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Fumalic acid (Ferulic acid)
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Hydroxy-3-methoxycinnamic acid
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Purity: 98.0%
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Contact: Ms Wang

1135-24-6

1135-24-6 structure

1135-24-6 structure

Name: ferulic acid
Chemical Name: ferulic acid
CAS Number: 1135-24-6
Molecular Formula: C₁₀H₁₀O₄
Molecular Weight: 194.184
Catalog: API Nervous system medication Brain metabolism regulating drug
Create Date: 2018-07-23 15:20:08
Modify Date: 2024-01-01 18:06:00
Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.

Name	ferulic acid
Synonyms	FERULLIC ACID FERULIC ACID pure Fumalic acid conifericacid Forulic acid 3-(4-Hydroxy-3-methoxyphenyl)acrylic acid Ferulic acid 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)- Ferulicacid EINECS 208-679-7 4-hydroxy-3-methoxy-cinnamic acid 4-Hydroxy-3-methoxycinnamic acid MFCD00004400 ferulaic acid

Description	Ferulic acid is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively.
Related Catalog	Natural Products >> Phenylpropanoids Research Areas >> Cancer
Target	IC50: 3.78 μM (FGFR1), 12.5 μM (FGFR2)[1]
In Vitro	Ferulic acid (FA) is a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor with IC50s of 3.78 and 12.5 μM for FGFR1 and FGFR2, respectively. Ferulic acid exhibits great inhibitory activity on FGFR1 with an inhibitory rate of 92% at 1 µM. The proliferation of HUVEC stimulated by FGF1 is markedly decreased after Ferulic acid treatment ranging from 5 to 40 μM for 24 h. Ferulic acid does not exert significant cell viability up to 20 μM, but over 30 μM Ferulic acid exhibits a cytotoxic effect in HUVEC compare to the control. Ferulic acid inhibits FGF1-induced HUVEC migration and invasion in a dose-dependent manner. Ferulic acid markedly suppresses the FGF1-induced phosphorylation of PI3K and Akt. Ferulic acid treatments significantly inhibit MMP-2 and MMP-9 expression stimulated by FGF1[1].
In Vivo	Treatment with Ferulic acid (FA) potently inhibits FGF1-induced neovascularization. It is found that intragastric administration of Ferulic acid markedly inhibits tumor volume and tumor weight, as compare to the counterparts treated with DMSO. Furthermore, Ferulic acid treatment is well tolerated, and there is no significant difference in weight between the vehicle group and the FA-treated groups[1]. Ferulic acid (0.01, 0.1, 1 or 10 mg/kg) given by oral route decreases significantly the immobility time in the forced swimming test (FST) and tail suspension test (TST), whereas produces no effect in the open-field test. Results demonstrate that the administration of Ferulic acid (0.001 mg/kg, p.o.) boosts the antidepressant-like effect of fluoxetine (5 mg/kg, p.o.) in the TST[2].
Cell Assay	HUVEC (5×104 cells/well) are plated onto a gelatinized 24-well culture plate and cultured in ECGS containing 15% FBS. HUVEC are treated with DMSO (0.1%) or different concentrations of Ferulic acid (FA) (0, 2.5, 5, 10, 20, 30, 40 μM) for 24 h. Cell viability is determined by the MTT assay. After 4 h of incubation, the absorbance is measured at 450 nm with a microplate reader. The results are calculated from six replicates of each experiment. Three independent experiments are performed[1].
Animal Admin	Male Swiss mice (30 to 40 g) are maintained at 21 to 23°C with free access to water and food, under a 12:12 h light/dark cycle (lights on at 07:00 h). All manipulations are carried out between, 9:00 and 16:00 h, with each animal used only once. In order to investigate the antidepressant-like effect of Ferulic acid, Ferulic acid is administered at a dose range of 0.001 to 10 mg/kg, by oral route (p.o.) 60 min before the forced swimming test (FST), tail suspension test (TST) or open-field test. The control animals receive appropriate vehicle[2].
References	[1]. Yang GW, et al. Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis. Int J Mol Sci. 2015 Oct 12;16(10):24011-31. [2]. Zeni AL, et al. Ferulic acid exerts antidepressant-like effect in the tail suspension test in mice: evidence for the involvement of the serotonergic system. Eur J Pharmacol. 2012 Mar 15;679(1-3):68-74.

Density	1.3±0.1 g/cm3
Boiling Point	372.3±27.0 °C at 760 mmHg
Melting Point	168-172 °C(lit.)
Molecular Formula	C₁₀H₁₀O₄
Molecular Weight	194.184
Flash Point	150.5±17.2 °C
Exact Mass	194.057907
PSA	66.76000
LogP	1.64
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.627
Storage condition	-20°C Freezer
Water Solubility	soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UD3365500

CHEMICAL NAME :: 2-Propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-

CAS REGISTRY NUMBER :: 1135-24-6

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H10-O4

MOLECULAR WEIGHT :: 194.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >350 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Behavioral - rigidity (including catalepsy)

REFERENCE :: IJSIDW Indian Journal of Pharmaceutical Sciences. (Kalina, Santa Cruz (East), Bombay 400 029, India) V.40(2)- 1978- Volume(issue)/page/year: 49,77,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 857 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 38,1620,1990

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UD3365500
HS Code	1302199099

Precursor 8
141-82-2 121-33-5 4046-02-0 148-53-8
85011-57-0 203861-62-5 79-10-7 823788-11-0
DownStream 10
4046-02-0 3943-74-6 121-33-5 84272-48-0
498-02-2 56024-44-3 458-36-6 90843-62-2
458-35-5 19272-90-3

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%