115150-59-9

115150-59-9 structure

Name: (Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)
Chemical Name: Antagonist G
CAS Number: 115150-59-9
Molecular Formula: C₄₉H₆₆N₁₂O₆S
Molecular Weight: 951.19000
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-06-21 19:55:27
Modify Date: 2024-01-02 14:12:26
Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].

Name	Antagonist G
Synonyms	arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide AntagonistG,Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2 ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2 H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2

Description	Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
In Vitro	Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2]. Antagonist G activates JNK1 in SCLC cells[2]. Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2]. Cell Viability Assay[2] Cell Line: SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Inhibited cell growh.
References	[1]. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50(13):3968-73. [2]. A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83(7): 941–948.