(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)

Modify Date: 2024-01-02 14:12:26

(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11) Structure
(Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11) structure
 Common Name (Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)
CAS Number 115150-59-9 Molecular Weight 951.19000
Density 1.35g/cm3 Boiling Point N/A
Molecular Formula C49H66N12O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)


Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].

 Names

Name Antagonist G
Synonym More Synonyms

  Biological Activity

Description Antagonist G is a potent vasopressin antagonist. Antagonist G is also a weak antagonist of GRP and Bradykinin. Antagonist G induces AP-1 transcription and sensitizes cells to chemotherapy[1][2].
Related Catalog
In Vitro Antagonist G (0-100 μM) induces apoptosis is redox-sensitive and caspase-dependently in SCLC cells[2]. Antagonist G activates JNK1 in SCLC cells[2]. Antagonist G is not intrinsically a free radical oxygen donor but stimulates free radical generation specifically within SCLC cells (6.2-fold) and increases the activity of the redox-sensitive transcription factor AP-1 by 61%[2]. Cell Viability Assay[2] Cell Line: SCLC cell lines NCI-H69, NCI-H510 and CHO-K1 cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Inhibited cell growh.
References

[1]. P J Woll, et al. A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res. 1990 Jul 1;50(13):3968-73.

[2]. A C MacKinnon, et al. [Arg6, D-Trp7,9, NmePhe8]-substance P (6–11) (antagonist G) inducesP-1 transcription and sensitizes cells to chemotherapy. Br J Cancer. 2000 Oct; 83(7): 941–948.

 Chemical & Physical Properties

Density 1.35g/cm3
Molecular Formula C49H66N12O6S
Molecular Weight 951.19000
Exact Mass 950.49500
PSA 324.60000
LogP 6.47350
Index of Refraction 1.666

 Synonyms

arginyl-tryptophyl-n-methylphenylalanyl-tryptophyl-leucyl-methioninamide
AntagonistG,Arg-D-Trp-N-Methyl-Phe-D-Trp-Leu-Met-NH2
ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
H-ARG-D-TRP-N-ME-PHE-D-TRP-LEU-MET-NH2
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Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11)
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(ARG6,D-TRP7,9,N-ME-PHE8)-SUBSTANCEP(6-11)
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(Pyr5,N-Me-Phe8,Sar9)-Substance P (5-11)
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(TYR6,D-PHE7,D-HIS9)-SUBSTANCE P (6-11)
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substance P (6-11), Arg(6)-Trp(7,9)-Me-Phe(8)-
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substance P (6-11), N(alpha)-(3-iododesaminotyrosyl)-
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substance P (6-11), N(1,6)(beta-glucopyranosyl)Glu(5)-Pro(9)-
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substance P (6-11), pGlu(6)-N-MeLeu(10)-
77160-86-2
substance P (6-11), pGlu(6)-N-MePhe(7)-
77160-85-1
Chemsrc provides CAS#:115150-59-9 MSDS, density, melting point, boiling point, structure, etc. Its name is (Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)>> amp version: (Arg6,D-Trp7.9,N-Me-Phe8)-Substance P (6-11)

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