Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11)

Modify Date: 2024-01-02 14:36:53

Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11) structure	Common Name	Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11)
	CAS Number	106128-89-6	Molecular Weight	841.97000
	Density	1.29 g/cm3	Boiling Point	1262.6ºC at 760 mmHg
	Molecular Formula	C₄₀H₅₅N₇O₁₁S	Melting Point	N/A
	MSDS	N/A	Flash Point	717.4ºC

Use of Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11)

Senktide is a tachykinin NK3 receptor agonist.

Name	Senktide
Synonym	More Synonyms

Description	Senktide is a tachykinin NK3 receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Peptides
Target	NK3 receptor[1]
In Vitro	The selective NK3 receptor agonist Senktide excites 24 of 31 dopaminergic neurons in the substantia nigra pars compacta in a concentration-dependent manner. The effective concentration range is between 3 to 3000 nm. The mean EC50 for Senktide is 41.2±9 nm (n=5)[2].
In Vivo	I.c.v. injection of Senktide causes a dose-dependent increase in total distance traveled (F6,72=6.344, P<0.001). This increase reaches statistical significance compare to the vehicle-treated group at 0.06 nmol and higher. The Senktide-induced increase in locomotor activity brought about by 0.1 nmol of Senktide is significantly and dose-dependently decreased by the tachykinin NK3 receptor antagonists talnetant at 30 mg/kg and SB222200 at 30 mg/kg, but not by osanetant, when tested in parallel in a single experiment (F7,78=10.32, P<0.001), although a non-significant reduction is observed. However, when tested using another vehicle (Vitamin E and glycofurol), osanetant does decrease activity significantly compare to Senktide-treated gerbils (F2,30=10.10, P<0.001)[1].
Cell Assay	Experiments are performed on brain slices (300 μM thick) from 150 g male Wistar rats and extracellular recordings are made by conventional techniques. Drugs (including Senktide) are applied by bath perfusion and removal is achieved simply by returning to the control drug-free solution. Extracellular electrodes are filled with aCSF and have resistances of 5 to 14 MΩ. For intracellular recordings, electrodes are filled with 1 M potassium acetate and have d.c. resistances of 70 to 110 MΩ. Neurons are considered to be dopaminergic if they have a characteristic waveform, slow firing rate (~5 Hz) and inhibitory response to dopamine[2].
Animal Admin	For the Senktide dose-response curve, gerbils are first allowed to habituate to the test area for 30 min. Animals (n=10 to 12 per drug treatment group) are anesthetized with isoflurane, a small incision is made in the skin over bregma, and an injection of Senktide at 0.01, 0.03, 0.06, 0.1, 0.3 or 0.6 nmol in 5 μL of vehicle is placed i.c.v. using a syringe with a 4.5 mm long needle. Wounds are clipped shut, and animals allowed to awaken from anesthesia, then placed directly into the locomotor activity boxes and recording commenced. For testing of the NK1 receptor antagonist aprepitant (1, 3 or 10 mg/kg p.o.), gerbils are first treated with aprepitant or vehicle (0.9% NaCl with 0.3% Tween80) and returned to the home cage for 90 min. Animals are then placed in the open field for 30 min of habituation. During the last 5 min of habituation, 0.03 nmol Senktide is injected i.c.v[1].
References	[1]. Nordquist RE, et al. The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur J Pharmacol. 2008 Dec 14;600(1-3):87-92. [2]. Keegan KD, et al. The selective NK3 receptor agonist senktide excites a subpopulation of dopamine-sensitiveneurones in the rat substantia nigra pars compacta in vitro. Br J Pharmacol. 1992 Jan;105(1):3-5.

Density	1.29 g/cm3
Boiling Point	1262.6ºC at 760 mmHg
Molecular Formula	C₄₀H₅₅N₇O₁₁S
Molecular Weight	841.97000
Flash Point	717.4ºC
Exact Mass	841.36800
PSA	317.59000
LogP	2.99010
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.579
Storage condition	-20°C

MSDS(Chinese)

RIDADR	NONH for all modes of transport

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