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171436-38-7

171436-38-7 structure
171436-38-7 structure
  • Name: SLIGRL-NH2 2TFA
  • Chemical Name: sligrl-nh2
  • CAS Number: 171436-38-7
  • Molecular Formula: C29H56N10O7
  • Molecular Weight: 656.81800
  • Catalog: Peptides
  • Create Date: 2018-12-24 18:01:57
  • Modify Date: 2024-01-13 14:47:46
  • Protease-Activated Receptor-2 Activating Peptide is an agonist of Protease-Activated Receptor-2 (PAR-2).
Name sligrl-nh2
Synonyms SER-LEU-ILE-GLY-ARG-LEU-AMIDE
H2N-SLIGRL-AMIDE
Ser-Leu-Ile-Gly-Arg-Leu-NH2
SLIGRLAMIDE
H-SER-LEU-ILE-GLY-ARG-LEU-NH2
PAR2-AP
REF DUPL: H-Ser-Leu-Ile-Gly-Arg-Leu-NH2
SER-LEU-ILE-GLY-ARG-LEU-NH2
Protease-Activated Receptor-2 Activating Peptide
Description Protease-Activated Receptor-2 Activating Peptide is an agonist of Protease-Activated Receptor-2 (PAR-2).
Related Catalog
Target

PAR-2[1]

In Vitro Protease-Activated Receptor-2 Activating Peptide (SLIGRL-NH2) is an agonist of PAR-2 and MrgprC11[1]. Protease-Activated Receptor-2 Activating Peptide (SLIGRL-NH2) causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 µM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 µM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].
Kinase Assay Tissues are routinely contracted with 100 mM potassium chloride (KCl) to test their viability. Then, after re-equilibration for 20 min in fresh buffer, tissues are contracted with 1 µM of phenylephrine and a test concentration of 1 µM ACh is added and the presence or absence of a relaxant response is monitored to verify the presence or absence of an intact functional endothelium. The contractile response to phenylephrine is expressed as a percentage of the contractile response caused by 100 mM KCl (% KCl). Upon standardizing the preparation with the use of KCl and ACh, the effects of added SLIGRL-NH2, 2-furoyl-LIGRLO-NH2, LRGILS-NH2, LSIGRL-NH2 and 2-furoyl-OLRGIL-NH2 on the tension of the phenylephrine-contracted preparations (1 µM phenylephrine) is monitored for tissues with/without an intact endothelium and with/without adherent PVAT. Relaxation (%) is expressed as a percentage reduction of the plateau tension developed in the presence of phenylephrine. The effects of the inhibitors (L-NAME, ODQ, indomethacin, 4-aminopyridine, combined apamin + charybdotoxin, glibenclamide, genistein, H89 and catalase) are measured by treating the tissues with the inhibitors for 15 min before their contraction with 1 µM phenylephrine, then followed by the addition of test concentrations of SLIGRL-NH2, 2-furoyl-LIGRLO-NH2, LRGILS-NH2, LSIGRL-NH2 and 2-furoyl-OLRGIL-NH2. In most experiments evaluating a role for PAR2, SLIGRL-NH2 is used at a concentration of 20 µM to ensure selectivity for PAR2[2].
References

[1]. Akiyama T, et al. Behavioral model of itch, alloknesis, pain and allodynia in the lower hindlimb and correlativeresponses of lumbar dorsal horn neurons in the mouse. Neuroscience. 2014 Apr 25;266:38-46.

[2]. Li Y, et al. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. Br J Pharmacol. 2011 Dec;164(8):1990-2002.
Density 1.342g/cm3
Molecular Formula C29H56N10O7
Molecular Weight 656.81800
Exact Mass 656.43300
PSA 296.74000
LogP 1.79430
Storage condition 2-8℃
Safety Phrases 22-24/25

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title: CAS No. 171436-38-7 | Chemsrc address: https://www.chemsrc.com/en/baike/587349.html

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