- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Aromadendrin
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- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- BioBioPha
- China
- Product Name: Aromadendrin
- Price: ￥Inquiry/5mg
- Purity: 98.0%
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- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Aromadendrin
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- DC Chemicals Limited
- China
- Product Name: Aromadendrin
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: aromadedrin
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480-20-6
480-20-6 structure
- Name: Aromadendrin
- Chemical Name: (+)-dihydrokaempferol
- CAS Number: 480-20-6
- Molecular Formula: C15H12O6
- Molecular Weight: 288.252
- Catalog: Natural product Flavonoids
- Create Date: 2018-05-12 08:00:00
- Modify Date: 2024-01-04 18:04:42
-
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].
| Name | (+)-dihydrokaempferol |
|---|---|
| Synonyms |
4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R-trans)-
Katuranin (2R,3R)-3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one (+)-dihydrokaempferol Aromadedrin Aromadendrin 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)- DIHYDROKAEMPFEROL |
| Description | Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1]. |
|---|---|
| Related Catalog | |
| Target |
Apoptosis; Bcl-2; Bcl-xL[1] |
| In Vitro | Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1]. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1]. Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time: 48 hours Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Induced apoptosis in RA-FLSs. Western Blot Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 639.0±55.0 °C at 760 mmHg |
| Molecular Formula | C15H12O6 |
| Molecular Weight | 288.252 |
| Flash Point | 247.3±25.0 °C |
| Exact Mass | 288.063385 |
| PSA | 107.22000 |
| LogP | 2.42 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.729 |
| Storage condition | ?20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P273-P501 |
| Hazard Codes | N,Xn |
| Risk Phrases | 50-22 |
| Safety Phrases | 61 |
| RIDADR | UN 3077 9 / PGIII |
|
~%
480-20-6 |
| Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377 |
|
~%
480-20-6 |
| Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377 |
|
~%
480-20-6 |
| Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377 |
|
~%
480-20-6 |
| Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377 |
| Precursor 4 | |
|---|---|
| DownStream 3 | |
