Aromadendrin

Modify Date: 2024-01-04 18:04:42

Aromadendrin Structure
Aromadendrin structure
Common Name Aromadendrin
CAS Number 480-20-6 Molecular Weight 288.252
Density 1.6±0.1 g/cm3 Boiling Point 639.0±55.0 °C at 760 mmHg
Molecular Formula C15H12O6 Melting Point N/A
MSDS Chinese USA Flash Point 247.3±25.0 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Aromadendrin


Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].

 Names

Name (+)-dihydrokaempferol
Synonym More Synonyms

 Aromadendrin Biological Activity

Description Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic drugs[1].
Related Catalog
Target

Apoptosis; Bcl-2; Bcl-xL[1]

In Vitro Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs[1]. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively)[1]. Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP[1]. Cell Proliferation Assay[1] Cell Line: Normal synoviocyte cells; RA-FLS cells Concentration: 0.3 μM, 3 μM, 30 μM, 300 μM Incubation Time: 48 hours Result: Decreased the proliferation of RA-FLSs. Apoptosis Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Induced apoptosis in RA-FLSs. Western Blot Analysis[1] Cell Line: RA-FLS cells Concentration: 3 μM, 30 μM Incubation Time: 48 hours Result: Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression.
References

[1]. Zhang Y, et al. Apoptosis Effects of Dihydrokaempferol Isolated from Bauhinia championii on Synoviocytes. Evid Based Complement Alternat Med. 2018 Dec 2;2018:9806160.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 639.0±55.0 °C at 760 mmHg
Molecular Formula C15H12O6
Molecular Weight 288.252
Flash Point 247.3±25.0 °C
Exact Mass 288.063385
PSA 107.22000
LogP 2.42
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.729
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P273-P501
Hazard Codes N,Xn
Risk Phrases 50-22
Safety Phrases 61
RIDADR UN 3077 9 / PGIII

 Synthetic Route

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Aromadendrin Structure

Aromadendrin

CAS#:480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377

~%

Aromadendrin Structure

Aromadendrin

CAS#:480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377

~%

Aromadendrin Structure

Aromadendrin

CAS#:480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377

~%

Aromadendrin Structure

Aromadendrin

CAS#:480-20-6

Literature: Takahashi, Hiroshi; Kubota, Yumiko; Igushi, Mieko; Fang, Lin; Onda, Masayuki Heterocycles, 1986 , vol. 24, # 2 p. 369 - 377

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 Synonyms

4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R-trans)-
Katuranin
(2R,3R)-3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
(+)-dihydrokaempferol
Aromadedrin
Aromadendrin
4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)-
DIHYDROKAEMPFEROL
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