4298-15-1
4298-15-1 structure
- Name: Cletoquine
- Chemical Name: 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol
- CAS Number: 4298-15-1
- Molecular Formula: C16H22ClN3O
- Molecular Weight: 307.81800
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2018-03-23 08:00:00
- Modify Date: 2024-01-02 11:33:32
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Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
| Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol |
|---|---|
| Synonyms |
Cletoquine [INN:BAN]
GNF-Pf-1952 2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}amino)ethanol Cletoquine Cletoquina Cletochina Desethylhydroxychloroquine Cletoquinum Cletochina [DCIT] |
| Description | Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Chikungunya virus (CHIKV)[2] |
| In Vivo | Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3]. |
| References |
| Density | 1.212 g/cm3 |
|---|---|
| Boiling Point | 514.7ºC at 760 mmHg |
| Molecular Formula | C16H22ClN3O |
| Molecular Weight | 307.81800 |
| Flash Point | 265.1ºC |
| Exact Mass | 307.14500 |
| PSA | 57.18000 |
| LogP | 3.51460 |
| Index of Refraction | 1.623 |
| HS Code | 2933499090 |
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| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |