53155-25-2

53155-25-2 structure

Name: Euscaphic acid
Chemical Name: euscaphic acid
CAS Number: 53155-25-2
Molecular Formula: C₃₀H₄₈O₅
Molecular Weight: 488.699
Catalog: Natural product Moss
Create Date: 2018-07-19 19:18:45
Modify Date: 2024-01-02 16:37:51
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].

Name	euscaphic acid
Synonyms	Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2α,3α)- Jacarandic acid (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid 2α,3α,19α-Trihydroxyurs-12-en-28-oic acid (2α,3α)-2,3,19-Trihydroxyurs-12-en-28-oic acid tormentic acid Euscaphic acid 2,3,19-trihydroxyurs-12-en-28-oic acid

Description	Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	IC50: 61 μM (calf DNA polymerase α); 108 μM (rat DNA polymerase β)[1]; apoptosis[2]
In Vitro	Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2].
References	[1]. Murakami C, et al. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochim Biophys Acta. 2002 Apr 29;1596(2):193-200. [2]. Dai W, et al. Euscaphic acid inhibits proliferation and promotes apoptosis of nasopharyngeal carcinoma cells by silencing the PI3K/AKT/mTOR signaling pathway. Am J Transl Res. 2019 Apr 15;11(4):2090-2098.

Hazard Codes	Xi

Precursor 0
DownStream 1
13850-15-2