6320-51-0

6320-51-0 structure

Name: NSC31205
Chemical Name: 5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
CAS Number: 6320-51-0
Molecular Formula: C₁₁H₉NO₃S
Molecular Weight: 235.25900
Catalog: Signaling Pathways JAK/STAT Signaling Pim
Create Date: 2016-08-12 05:39:52
Modify Date: 2024-01-03 16:13:20
Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer[1].

Name	5-[(4-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione
Synonyms	5-(4-methoxy-benzylidene)-thiazolidine-2,4-dione 5-(4-methoxybenzylidene)-2,4-thiazolidinedione (Z)-5-(4-methoxybenzylidene)-2,4-thiazolidinedione (Z)-5-4-(methoxybenzylidene)thiazolidine-2,4-dione 2,4-Thiazolidinedione,5-p-methoxybenzylidene (5Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione (Z)-5-(4-methoxyphenylmethylene)-2,4-thiazolidinedione

Description	Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> Pim
In Vitro	Pim-1/2 kinase inhibitor 1 (compound D14) (varying concentrations; 48 h) shows cytotoxicity to PC3 cells, with an IC of 11 µM[1]. Cell Cytotoxicity Assay[1] Cell Line: PC3 cells Concentration: varying concentrations Incubation Time: 48 h Result: Inhibited PC3 cells with an IC of 11 µM.
References	[1]. Charles D. Smith, et al. Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer. Patent US20110263664A1.