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  • DC Chemicals Limited
  • China
  • Product Name: BPH-1358
  • Price: ¥650.0/100mg ¥1100.0/250mg ¥2200.0/1g
  • Purity: 98.0%
  • Stocking Period: Inquiry
  • Contact: Tony Cao


5352-53-4

5352-53-4 structure
5352-53-4 structure
  • Name: BPH-1358
  • Chemical Name: N-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-4-[4-[[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]carbamoyl]phenyl]benzamide,hydrochloride
  • CAS Number: 5352-53-4
  • Molecular Formula: C32H30Cl2N6O2
  • Molecular Weight: 565.06500
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2017-10-05 20:16:31
  • Modify Date: 2024-01-10 19:13:07
  • BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].

Name N-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-4-[4-[[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]carbamoyl]phenyl]benzamide,hydrochloride
Description BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].
Related Catalog
Target

IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (undecaprenyl diphosphate synthase)[2]

In Vitro BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1].
In Vivo BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1].
References

[1]. Zhu W, et al. Antibacterial drug leads: DNA and enzyme multitargeting. J Med Chem. 2015 Feb 12;58(3):1215-27.

[2]. Liu YL, et al. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. ACS Med Chem Lett. 2015 Jan 29;6(3):349-54.

Density 1.32g/cm3
Molecular Formula C32H30Cl2N6O2
Molecular Weight 565.06500
Exact Mass 564.20400
PSA 106.98000
LogP 5.03460
Index of Refraction 1.704