BPH-1358
Modify Date: 2024-01-10 19:13:07
BPH-1358 structure
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Common Name | BPH-1358 | ||
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| CAS Number | 5352-53-4 | Molecular Weight | 565.06500 | |
| Density | 1.32g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C32H30Cl2N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BPH-1358BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
| Name | N-[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-4-[4-[[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]carbamoyl]phenyl]benzamide,hydrochloride |
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| Description | BPH-1358 (NSC50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor with IC50s of 1.8 μM and 110 nM, respectively, and is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2]. |
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| Related Catalog | |
| Target |
IC50: 1.8 μM (human bisphosphonate farnesyl diphosphate synthase)[1]; 100 nM (undecaprenyl diphosphate synthase)[2] |
| In Vitro | BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) as well as S. aureus UPPS (SaUPPS) with an IC50 of 110 nM. BPH-1358 against E. coli and S. aureus with EC50 of 300 nM and 290 nM, respectively[1]. |
| In Vivo | BPH-1358 is active against S. aureus in vivo (20/20 mice survived in an i.p. infection model with a MRSA strain)[1]. |
| References |
| Density | 1.32g/cm3 |
|---|---|
| Molecular Formula | C32H30Cl2N6O2 |
| Molecular Weight | 565.06500 |
| Exact Mass | 564.20400 |
| PSA | 106.98000 |
| LogP | 5.03460 |
| Index of Refraction | 1.704 |