72156-72-0

72156-72-0 structure

Name: Phenacetin-13C
Chemical Name: N-(4-ethoxyphenyl)acetamide
CAS Number: 72156-72-0
Molecular Formula: C₁₀H₁₃NO₂
Molecular Weight: 180.20800
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2019-01-17 19:17:39
Modify Date: 2024-01-27 21:00:23
Phenacetin-13C is the 13C labeled Phenacetin[1]. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[2][3][4].

Name	N-(4-ethoxyphenyl)acetamide
Synonyms	N-(4-Ethoxy-1-13C-phenyl)acetamide MFCD00083951 N-4-((1-13C)Ethoxy)phenylacetamide Phenacetin-13C1 (ethoxy-1-13C) p-Acetophenetidide-ethoxy-1-13C (<1-13C>ethoxy)phenacetin Phenacetin-ethoxy-1-13C

Description	Phenacetin-13C is the 13C labeled Phenacetin[1]. Phenacetin (Acetophenetidin) is a non-opioid analgesic/antipyretic agent. Phenacetin is a selective COX-3 inhibitor. Phenacetin is used as probe of cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats[2][3][4].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. [3]. Xiao-Meng He, et al. Effects of long-term smoking on the activity and mRNA expression of CYP isozymes in rats. J Thorac Dis. 2015 Oct 7(10): 1725–1731. [4]. Na Gao, et al. Inhibition of Baicalin on Metabolism of Phenacetin, a Probe of CYP1A2, in Human Liver Microsomes and in Rats. PLoS One. 2014 9(2): e89752.

75560-39-3

103-90-2

~96%

72156-72-0

Literature: Kurumaya; Kajiwara; Abei; Hirano; Kokubun Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 7 p. 2679 - 2681

108-24-7

117005-54-6

~73%

72156-72-0

Literature: Kurumaya; Kajiwara; Abei; Hirano; Kokubun Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 7 p. 2679 - 2681

100-02-7

72156-72-0

Literature: Kurumaya; Kajiwara; Abei; Hirano; Kokubun Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 7 p. 2679 - 2681

117005-53-5

72156-72-0

Literature: Kurumaya; Kajiwara; Abei; Hirano; Kokubun Chemical and pharmaceutical bulletin, 1988 , vol. 36, # 7 p. 2679 - 2681

Precursor 4
75560-39-3 103-90-2 108-24-7 100-02-7
DownStream 0