40312-34-3

40312-34-3 structure

Name: T62
Chemical Name: (2-amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-(4-chlorophenyl)methanone
CAS Number: 40312-34-3
Molecular Formula: C₁₅H₁₄ClNOS
Molecular Weight: 291.79600
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-06-21 11:23:27
Modify Date: 2024-01-16 08:22:01
Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

Name	(2-amino-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-(4-chlorophenyl)methanone
Synonyms	2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene UNII-9Q765ZIF8L (2-Amino-4,5,6,7-tetrahydrobenzo[b]thiophen-3-yl)(4-chlorophenyl)methanone T62 (2-amino-4,5,6,7-tetrahydro-1-benzothien-3-yl)(4-chlorophenyl)methanone

Description	Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Adenosine A1 receptor[1]
In Vivo	Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1]. Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery[1] Dosage: 0.3 μg, 0.5 μg, 1 μg, and 3 μg Administration: Intrathecal administration Result: Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
References	[1]. Obata H, et al. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May;100(5):1258-62. [2]. Li X, et al. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun;305(3):950-5. [3]. Soudijn W, et al. Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov Today. 2004 Sep 1;9(17):752-8.

Density	1.337g/cm3
Boiling Point	527ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄ClNOS
Molecular Weight	291.79600
Flash Point	272.5ºC
Exact Mass	291.04800
PSA	71.33000
LogP	4.67470
Index of Refraction	1.658

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2934999090

880359-28-4

~80%

40312-34-3

Literature: Baraldi, Pier Giovanni; Pavani, Maria Giovanna; Leung, Edward; Moorman, Allan R.; Varani, Katia; Vincenzi, Fabrizio; Borea, Pier Andrea; Romagnoli, Romeo Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 5 p. 1402 - 1404

108-94-1

4640-66-8

~46%

40312-34-3

Literature: Van Der Klein, Pieter A. M.; Kourounakis, Angeliki P.; IJzerman, Ad P. Journal of Medicinal Chemistry, 1999 , vol. 42, # 18 p. 3629 - 3635

880359-27-3

40312-34-3

860697-28-5

40312-34-3

108-94-1

40312-34-3

Precursor 5
880359-28-4 108-94-1 4640-66-8 880359-27-3
860697-28-5
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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