173531-58-3
173531-58-3 structure
- Name: Naphthoquine Phosphate
- Chemical Name: 2-[(tert-butylamino)methyl]-4-[(7-chloroquinolin-4-yl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol,phosphoric acid
- CAS Number: 173531-58-3
- Molecular Formula: C24H34ClN3O9P2
- Molecular Weight: 605.942
- Catalog: API Antiparasitic drug Antimalarial
- Create Date: 2018-08-17 11:58:29
- Modify Date: 2024-01-02 18:12:56
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Naphthoquine phosphate is antimalarial drug.IC50 Value: N/ATarget: AntiparasiticNaphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset of schizonticidal action and a short half-life. Parasite clearance is, however, often incomplete when it is employed as a single agent unless high dosages are used over several days, but such a regimen may reduce patient compliance and increase the danger of toxicity. Naphthoquine phosphate, by contrast, has a slower onset of action and a longer half-life, associated with a low recrudescence rate.
| Name | 2-[(tert-butylamino)methyl]-4-[(7-chloroquinolin-4-yl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol,phosphoric acid |
|---|---|
| Synonyms |
1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt)
Naphthoquine phosphate 4-[(7-Chloro-4-quinolinyl)amino]-2-{[(2-methyl-2-propanyl)amino]methyl}-5,6,7,8-tetrahydro-1-naphthalenol phosphate (1:2) CS-0739 Naphthoquine (phosphate) |
| Description | Naphthoquine phosphate is antimalarial drug.IC50 Value: N/ATarget: AntiparasiticNaphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset of schizonticidal action and a short half-life. Parasite clearance is, however, often incomplete when it is employed as a single agent unless high dosages are used over several days, but such a regimen may reduce patient compliance and increase the danger of toxicity. Naphthoquine phosphate, by contrast, has a slower onset of action and a longer half-life, associated with a low recrudescence rate. |
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| Related Catalog | |
| References |
| Molecular Formula | C24H34ClN3O9P2 |
|---|---|
| Molecular Weight | 605.942 |
| Exact Mass | 605.145874 |
| PSA | 232.32000 |
| LogP | 4.71100 |
| Storage condition | 2-8℃ |