Name | 5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one |
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Description | JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1]. |
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Related Catalog | |
Target |
JAK3:38 nM (IC50) JAK2:600 nM (IC50) |
References |
Molecular Formula | C18H13N3O |
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Molecular Weight | 287.32 |
Exact Mass | 287.10600 |
PSA | 57.78000 |
LogP | 3.70740 |