JAK3-IN-14

Modify Date: 2024-02-10 12:03:26

JAK3-IN-14 structure	Common Name	JAK3-IN-14
	CAS Number	454234-24-3	Molecular Weight	287.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK3-IN-14

JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].

Name	5-pyridin-3-yl-3-(1H-pyrrol-2-ylmethylidene)-1H-indol-2-one

Description	JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
Target	JAK3:38 nM (IC50) JAK2:600 nM (IC50)
References	[1]. Chen JJ, et al. Development of pyrimidine-based inhibitors of Janus tyrosine kinase 3. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5633-8.

Molecular Formula	C₁₈H₁₃N₃O
Molecular Weight	287.32
Exact Mass	287.10600
PSA	57.78000
LogP	3.70740

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: JAK3-IN-14
Price: Click To Check
Purity: 98.98%
Delivery: 10 Day
Contact: Yang
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