32860-54-1

32860-54-1 structure

Name: 5-methylaminomethyl-2-thiouridine
Chemical Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(methylaminomethyl)-2-sulfanylidenepyrimidin-4-one
CAS Number: 32860-54-1
Molecular Formula: C₁₁H₁₇N₃O₅S
Molecular Weight: 303.33500
Catalog: Research Areas Others
Create Date: 2017-05-12 00:13:32
Modify Date: 2024-01-30 12:08:59
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].

Name	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(methylaminomethyl)-2-sulfanylidenepyrimidin-4-one
Synonyms	5-methylaminomethyl-2-thiouridine Uridine,5-[(methylamino)methyl]-2-thio 2-Thio-5-(N-methylaminomethyl)uridine 5-N-Methylaminomethyl-2-thiouridine 2-Thio-5-methylaminomethyluridine

Description	Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	An E. coli strain deficient in mnm5s2U is more vulnerable to oxidative RNA damage compared to its wildtype strain suggesting an auxiliary function for the mnm5s2U modification[1].
References	[1]. Mariana Estevez, et al. Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides. Front Mol Biosci. 2021 Jul 1;8:697149.