96760-69-9

96760-69-9 structure

Name: Adenosine amine congener
Chemical Name: [3h]-adac
CAS Number: 96760-69-9
Molecular Formula: C₂₈H₃₂N₈O₆
Molecular Weight: 576.60400
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-07-13 17:22:13
Modify Date: 2024-01-08 08:52:22
Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].

Name	[3h]-adac
Synonyms	Adenosine amine congener hydrate Adenosine Amine Congener

Description	Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. Adenosine amine congener also has neuroprotective effects[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A1 adenosine receptor[1][2]
In Vitro	Adenosine amine congener can reduce oxidative stress in the noise-exposed cochlea, leading to protection of sensory hair cells. Adenosine amine congener also can reduce cisplatin-induced apoptosis in cochlear tissues, particularly in sensory hair cells and strial marginal cells. The mechanisms of otoprotection by Adenosine amine congener include inhibition of glutamate release via presynaptic A1 receptors and inhibition of voltage-gated Ca2+ channels, which can prevent activation of apoptotic and necrotic cell death pathways[1].
In Vivo	Adenosine amine congener (25-300 μg/kg/day; intraperitoneal injection; daily; for 5 days; male Wistar rats) treatment is most effective in the first 24 hours after noise exposure at doses >50 μg/kg, providing up to 21 dB protection. Adenosine amine congener mitigates noise-induced hearing loss in a dose- and time-dependent manner[1]. Animal Model: Male Wistar rats (8-10 weeks old) treated with noise exposure[1] Dosage: 25 μg/kg/day, 50 μg/kg/day, 100 μg/kg/day, 200 μg/kg/day, and 300 μg/kg/day Administration: Intraperitoneal injection; daily; for 5 days Result: Most effective in the first 24 hours after noise exposure at doses >50 μg/kg, and provided up to 21 dB protection (averaged across 8-28 kHz).
References	[1]. Vlajkovic SM, et al. Adenosine amine congener as a cochlear rescue agent. Biomed Res Int. 2014;2014:841489. [2]. Vlajkovic SM, et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 2010 Jun;6(2):273-81.

Molecular Formula	C₂₈H₃₂N₈O₆
Molecular Weight	576.60400
Exact Mass	576.24400
PSA	209.77000
LogP	1.21720

1197-55-3

96760-69-9

Literature: Jacobson; Kirk; Padgett; Daly Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1341 - 1346

Precursor 1
1197-55-3
DownStream 0

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