1135-66-6
1135-66-6 structure
- Name: Isolongifolene
- Chemical Name: Isolongifolene
- CAS Number: 1135-66-6
- Molecular Formula: C15H24
- Molecular Weight: 204.351
- Catalog: Flavors and spices Synthetic spice Hydrocarbon spice Olefin
- Create Date: 2018-03-22 08:00:00
- Modify Date: 2024-01-02 11:07:13
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Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1].
| Name | Isolongifolene |
|---|---|
| Synonyms |
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-
2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1R)-2,2,7,7-Tetramethyltricyclo[6.2.1.01.6]undec-5-ene EINECS 214-494-2 (1R,8S)-2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)-(-)- 2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene trans-Isolongifolene 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyI-2H-2,4a-methanonaphthalene MFCD00042616 UNII:PX6N25M90H iso-Longifolene |
| Description | Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM Incubation Time: 26 hours Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 266.5±7.0 °C at 760 mmHg |
| Molecular Formula | C15H24 |
| Molecular Weight | 204.351 |
| Flash Point | 102.6±13.0 °C |
| Exact Mass | 204.187805 |
| LogP | 6.36 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.518 |
| Hazard Codes | F+ |
|---|---|
| Risk Phrases | R10 |
| RIDADR | UN 2319 3/PG 3 |
| WGK Germany | 3 |
| Packaging Group | III |
| Hazard Class | 3.2 |
| HS Code | 2902199090 |
| Precursor 8 | |
|---|---|
| DownStream 1 | |
![1-(octahydro-7,7,8,8-tetramethyl-2,3b-methano-3bH-cyclopenta[1,3]cyclopropa[1,2]benzen-4-yl)ethanone structure](https://image.chemsrc.com/caspic/433/59056-72-3.png)
| HS Code | 2902199090 |
|---|---|
| Summary | 2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0% |