73340-41-7

73340-41-7 structure

Name: Methylnissolin
Chemical Name: (-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
CAS Number: 73340-41-7
Molecular Formula: C₁₇H₁₆O₅
Molecular Weight: 300.306
Catalog: Signaling Pathways MAPK/ERK Pathway ERK
Create Date: 2018-10-17 11:44:47
Modify Date: 2024-01-05 18:36:07
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].

Name	(-)-6aR,11aR-dihydro-3-hydroxy-9,10-dimethoxy-6H-benzofuro[3,2-c][1]-benzopyran
Synonyms	6H-Benzofuro[3,2-c][1]benzopyran-3-ol, 6a,11a-dihydro-9,10-dimethoxy- (-)-10-methoxymedicarpin 9,10-Dimethoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol 3-hydroxy-9,10-dimethoxypterocarpane 3-hydroxy-9,10-dimethoxypterocarpan 9-methoxynissolin (-)-methylnissolin Methylnissolin

Description	Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PDGFR Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	PDGFR:10 μM (IC50) ERK1 ERK2
References	[1]. Ohkawara S, et al. Astrapterocarpan isolated from Astragalus membranaceus inhibits proliferation of vascular smooth muscle cells. Eur J Pharmacol. 2005 Nov 21;525(1-3):41-7.