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Product Name: Isothipendyl
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Dayang Chem (Hangzhou) Co., Ltd.
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482-15-5

482-15-5 structure

482-15-5 structure

Name: Isothipendyl
Chemical Name: N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine
CAS Number: 482-15-5
Molecular Formula: C₁₆H₁₉N₃S
Molecular Weight: 285.40700
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-09-25 09:48:13
Modify Date: 2024-01-09 22:54:34
Isothipendyl (AY 56012), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist. Isothipendyl is a primary metabolite[1].

Name	N,N-dimethyl-1-pyrido[3,2-b][1,4]benzothiazin-10-ylpropan-2-amine
Synonyms	Actapront Odantol Nilergex Isothipendylum isothiopendyl Isothipendyl Udantol Andanton

Description	Isothipendyl (AY 56012), an azaphenothiazine derivative, is a potent histamine 1 (H1) receptor antagonist. Isothipendyl is a primary metabolite[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	Human Endogenous Metabolite

Density	1.167g/cm3
Boiling Point	421.3ºC at 760mmHg
Molecular Formula	C₁₆H₁₉N₃S
Molecular Weight	285.40700
Flash Point	208.6ºC
Exact Mass	285.13000
PSA	44.67000
LogP	3.69940
Vapour Pressure	2.63E-07mmHg at 25°C
Index of Refraction	1.62

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UU8571000

CHEMICAL NAME :: 10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(2-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 482-15-5

BEILSTEIN REFERENCE NO. :: 0256817

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H19-N3-S

MOLECULAR WEIGHT :: 285.44

WISWESSER LINE NOTATION :: T C666 BN DN ISJ B1Y1&N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 222 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958

95873-97-5 structure

95873-97-5

~%

482-15-5 structure

482-15-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

92316-06-8 structure

92316-06-8

~%

482-15-5 structure

482-15-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

91902-18-0 structure

91902-18-0

~%

482-15-5 structure

482-15-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

137-07-5 structure

137-07-5

~%

482-15-5 structure

482-15-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

261-96-1 structure

261-96-1

108-14-5 structure

108-14-5

~%

482-15-5 structure

482-15-5

Literature: Yale; Sowinski Journal of the American Chemical Society, 1958 , vol. 80, p. 1651,1653

6631-37-4 structure

6631-37-4

~%

482-15-5 structure

482-15-5

Literature: Schuler,W.A.; Klebe,H. Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180

261-96-1 structure

261-96-1

53309-35-6 structure

53309-35-6

~%

482-15-5 structure

482-15-5

Literature: Schuler,W.A.; Klebe,H. Justus Liebigs Annalen der Chemie, 1962 , vol. 653, p. 172 - 180

Precursor 7
92316-06-8 91902-18-0 137-07-5 261-96-1
108-14-5 6631-37-4 53309-35-6
DownStream 0