1394854-52-4
1394854-52-4 structure
- Name: GSK-J2
- Chemical Name: sodium,3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate
- CAS Number: 1394854-52-4
- Molecular Formula: C22H23N5O2
- Molecular Weight: 389.45
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2017-03-05 10:48:54
- Modify Date: 2024-01-06 18:12:23
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GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
| Name | sodium,3-[[2-pyridin-3-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoate |
|---|---|
| Synonyms |
Sodium 3-{[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]amino}propanoate
β-Alanine, N-[2-(3-pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-, sodium salt (1:1) gsk-j2 |
| Description | GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A. |
|---|---|
| Related Catalog | |
| In Vitro | GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC50 of > 100 μM and 49 μM, respectively[1]. |
| References |
[1]. Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2. |
| Molecular Formula | C22H23N5O2 |
|---|---|
| Molecular Weight | 389.45 |
| PSA | 94.07000 |
| LogP | 1.83370 |
| Storage condition | 2-8℃ |