Name | enalaprilat dihydrate |
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Synonyms |
MFCD00941393
ENALAPRILAT DIHYDRATE 2-[N-(1-Carboxy-3-phenylpropyl)alanyl]-1-pyrrolidinecarboxylic acid dihydrate EINECS 278-459-3 1-Pyrrolidinecarboxylic acid, 2-[2-[(1-carboxy-3-phenylpropyl)amino]-1-oxopropyl]-, hydrate (1:2) |
Description | Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM.Target: ACEEnalaprilat has high affinity for human endothelial ACE with IC50 of 1.94 nM in vitro binding assay by displacing a saturating concentration of [125I]351A, a radiolabeled lisinopril analogue from ACE binding sites, and shows bradykinin/angiotensin I selectivity ratio of 1.00 calculated from double displacement experiments [1]. Enalaprilat attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with IC50 of 90 mM [2].Administration of Enalaprilat induces a significant reduction of MAP at 70 minutes compared with the placebo group during haemorrhagic shock in rats, and results in a 50% reduction of CO, a general tendency of EB extravasation which is significant in the kidney and lungs, and a significant increase in ileal EB extravasation (53%) [3]. |
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Related Catalog | |
References |
Boiling Point | 563.5ºC at 760 mmHg |
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Melting Point | 211-215°C |
Molecular Formula | C18H28N2O7 |
Molecular Weight | 384.424 |
Flash Point | 294.6ºC |
Exact Mass | 384.189636 |
PSA | 125.40000 |
LogP | 1.32630 |
Index of Refraction | 1.579 |
Storage condition | -20°C Freezer |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
Risk Phrases | R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . |
Safety Phrases | S22-S26-S36/37/39 |
RIDADR | NONH for all modes of transport |
RTECS | TW3590600 |