1445251-22-8
1445251-22-8 structure
- Name: ME 0328
- Chemical Name: (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
- CAS Number: 1445251-22-8
- Molecular Formula: C19H19N3O2
- Molecular Weight: 321.37300
- Catalog: Biochemical Inhibitor DNA damage PARP inhibitor
- Create Date: 2017-05-22 12:56:26
- Modify Date: 2024-01-04 16:53:18
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ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM.
| Name | (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide |
|---|---|
| Synonyms | 3-(4-oxo-1H-quinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide |
| Description | ME0328 is a potent and selective ARTD3/PARP3 inhibitor with an IC50 of 0.89±0.28 μM. |
|---|---|
| Related Catalog | |
| Target |
ARTD3/PARP3:0.89 μM (IC50) ARTD1/PARP1:6.3 μM (IC50) ARTD2/PARP2:10.8 μM (IC50) ARTD6/TNKS2:34.3 μM (IC50) ARTD5/TNKS1:47.3 μM (IC50) ARTD10/PARP10:71.3 μM (IC50) |
| In Vitro | ME0328 is a potent and selective inhibitor of ARTD3/PARP3 that is active in cells. In in vitro histone H1 modification assay, ME0328 inhibits the transferase activity of ARTD3 with an IC50 of 0.89±0.28 μM. In human A549 cells, ME0328 and ME0355 (at 10 μM) delay the resolution of γH2AX-containing foci that serve as markers for DNA double strand break repair following γ-irradiation (2 Gy). In silico and in vitro physicochemical and metabolic profiling indicated that ME0328 is soluble, cell permeable, and metabolically stable in human liver microsomes and rat hepatocytes[1]. |
| References |
| Molecular Formula | C19H19N3O2 |
|---|---|
| Molecular Weight | 321.37300 |
| Exact Mass | 321.14800 |
| PSA | 78.60000 |
| LogP | 3.98570 |
| Appearance | white to beige |
| Storage condition | room temp |
| Water Solubility | DMSO: soluble10mg/mL, clear |
