1469337-95-8
1469337-95-8 structure
- Name: K-Ras(G12C) inhibitor 12
- Chemical Name: 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one
- CAS Number: 1469337-95-8
- Molecular Formula: C15H17ClIN3O3
- Molecular Weight: 449.671
- Catalog: Biochemical Inhibitor Cell Cycle Rho inhibitor
- Create Date: 2018-12-10 19:19:22
- Modify Date: 2024-01-02 16:52:41
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K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.IC50 value: 0.32 μM (EC50)Target: K-RasBinding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6).
| Name | 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one |
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| Synonyms |
1-(4-(2-((4-Chloro-2-hydroxy-5-iodophenyl)amino)acetyl)piperazin-1-yl)prop-2-en-1-one
2-Propen-1-one, 1-[4-[2-[(4-chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]- 1-(4-{[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl}-1-piperazinyl)-2-propen-1-one K-Ras(G12C) inhibitor 12 1-[4-[2-[(4-Chloro-2-hydroxy-5-iodophenyl)amino]acetyl]-1-piperazinyl]-2-propen-1-one |
| Description | K-Ras(G12C) inhibitor 12 is a K-Ras(G12C) inhibitor, the half-maximum effective concentration (EC50) for K-Ras(G12C) inhibitor 12 in H1792 cells is 0.32 μM.IC50 value: 0.32 μM (EC50)Target: K-RasBinding of K-Ras(G12C) inhibitor 12 to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. In the absence of K-Ras(G12C) inhibitor 12, K-Ras(G12C) shows a slight preference for GTP (relative affinity 0.6). |
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| Related Catalog | |
| References |
| Density | 1.736±0.06 g/cm3 |
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| Boiling Point | 680.2±55.0 °C at 760 mmHg |
| Molecular Formula | C15H17ClIN3O3 |
| Molecular Weight | 449.671 |
| Flash Point | 365.2±31.5 °C |
| Exact Mass | 449.000305 |
| PSA | 72.88000 |
| LogP | 2.84 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.674 |
| Water Solubility | Practically insoluble (0.01 g/L) (25 ºC) |
| HS Code | 2933599090 |
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| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |