Name | N-cyclohexyl-4-(1H-imidazol-5-yl)piperidine-1-carbothioamide |
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Synonyms |
Thioperamide
Tocris-0644 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-5-yl)-, (2Z)-2-butenedioate (1:1) N-Cyclohexyl-4-(1H-imidazol-5-yl)-1-piperidinecarbothioamide (2Z)-2-butenedioate (1:1) 1-Piperidinecarbothioamide, N-cyclohexyl-4-(1H-imidazol-4-yl)-, (2Z)-2-butenedioate (1:1) Lopac-T-123 N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide (2Z)-but-2-enedioate (1:1) thioperamine |
Description | Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a Ki of 4.3 nM for inhibition of [3H]histamine release. Thioperamide inhibits [3H]histamine synthesis with a Ki of 31 nM[1]. |
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Related Catalog | |
Target |
H3 Receptor |
In Vitro | Thioperamide inhibits [3H]-(R)α-MeHA binding rat brain and guinea-pig lung with Kis of 2.1 nM and 2.0 nM, respectively. Thioperamide competitively blocks H3-autoreceptors regulating [3H]histamine release with a mean apparent Ki of 4 nM[1]. Thioperamide (0.01-100 μM; 24 hours) promotes the viability of NE-4C stem cells in a concentration-dependent manner[2]. Cell Viability Assay[2] Cell Line: NE-4C stem cells Concentration: 0.01, 0.1, 1, 10, 100 μM Incubation Time: 24 hours Result: The viability of NE-4C stem cells increased significantly to 150.83±6.91% when (1 μM) was administrated, and increased to 145.11±14.52% and 132.02%±25.65% when 10 μM and 100 μM were administrated respectively. |
In Vivo | Thioperamide (5-20 mg/kg; i.p.) is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice[3]. Animal Model: Naive female C57BL/6J mice[3] Dosage: 5, 10 or 20 mg/kg Administration: Injections (i.p.) Result: Facilitated reconsolidation of a contextually-conditioned fear memory. |
References |
Density | 1.2 g/cm3 |
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Boiling Point | 499.5ºC at 760 mmHg |
Molecular Formula | C15H24N4S |
Molecular Weight | 408.515 |
Flash Point | 255.9ºC |
Exact Mass | 408.183136 |
PSA | 150.64000 |
LogP | 2.83690 |
Vapour Pressure | 4.12E-10mmHg at 25°C |
Index of Refraction | 1.614 |
Hazard Codes | Xi: Irritant; |
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Risk Phrases | R36/37/38 |
HS Code | 2933990090 |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |