65664-81-5

65664-81-5 structure

Name: Bis-ANS dipotassium
Chemical Name: Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
CAS Number: 65664-81-5
Molecular Formula: C₃₂H₂₂K₂N₂O₆S₂
Molecular Weight: 672.85300
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2018-10-08 09:38:22
Modify Date: 2024-01-02 09:23:06
Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].

Name	Bis-ANS,4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt
Synonyms	BIS-ANS BIS-ANS DIPOTASSIUM SALT 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid dipotassium salt 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISULFONIC ACID,POTASSIUM SALT potassium 8,8'-dianilino-5,5'-binaphthalene-1,1'-disulfonate 4,4'-dianilino-1,1'-binaphthyl-5,5'-disulfonic acid,dipot 8-Anilino-1-naphthalenesulfonic Acid Di 4,4'-dianilino-1,1'-binaphthyl-5,5'-di-sulfonic A 4,4'-DIANILINO-1,1'-BINAPHTHYL-5,5'-DISU LFONIC ACI

Description	Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Research Areas >> Neurological Disease
In Vitro	Bis-ANS is a fluorescent molecule that has been used to probe exposed hydrophobic patches in proteins and to monitor the formation of protein aggregates. Bis-ANS is a bivalent naphthalene sulfonate with aniline moieties. Bis-ANS modulates the liquid-liquid phase separation of TDP-43 low complexity domain (LCD)[2].
References	[1]. P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50. [2]. W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport

28836-03-5

~29%

65664-81-5

Literature: Hornback, Joseph M.; Gossage, Henry E. Journal of Organic Chemistry, 1985 , vol. 50, # 4 p. 541 - 543

Precursor 1
28836-03-5
DownStream 0