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58131-57-0

58131-57-0 structure

58131-57-0 structure

Name: NSC 207895
Chemical Name: 4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium
CAS Number: 58131-57-0
Molecular Formula: C₁₁H₁₃N₅O₄
Molecular Weight: 279.252
Catalog: Biochemical Inhibitor Apoptosis Mdm2 activator
Create Date: 2018-12-09 12:29:29
Modify Date: 2024-01-09 17:26:19
NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].

Name	4-(4-methylpiperazin-1-yl)-7-nitro-3-oxido-2,1,3-benzoxadiazol-3-ium
Synonyms	7-(4-Methyl-1-piperazinyl)-4-nitrobenzofurazan 1-oxide Benzofurazan,4-(4-methyl-1-piperazinyl)-7-nitro-,3-oxide 7-(4-Methyl-1-piperazinyl)-4-nitro-2,1,3-benzoxadiazole 1-oxide B2368 2,1,3-Benzoxadiazole, 7-(4-methyl-1-piperazinyl)-4-nitro-, 1-oxide 7-(4-Methylpiperazin-1-yl)-4-nitro-2,1,3-benzoxadiazole 1-oxide

Description	NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
In Vitro	NSC-207895 (0.5 μM, 30 min), a MDM2 inhibitor, upregulates p53 protein levels[2]. NSC-207895, MDMX inhibitor, downregulates the expression of MDMX in AML cells at the mRNA and protein levels[3]. Western Blot Analysis[2] Cell Line: RAW 264.7 cells. Concentration: 0.5 μM. Incubation Time: 30 min (stimulated with LPS (100 ng/ml) for 6 h). Result: Upregulated p53 protein levels.
References	[1]. Laura Kapitzky, et al. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21;6:451. [2]. Erdenezaya Odkhuu, et al. Lipopolysaccharide downregulates the expression of p53 through activation of MDM2 and enhances activation of nuclear factor-kappa B. Immunobiology. 2015 Jan;220(1):136-41. [3]. Luis A Carvajal, et al. Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia. Sci Transl Med. 2018 Apr 11;10(436):eaao3003.

Density	1.6±0.1 g/cm3
Boiling Point	487.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₃N₅O₄
Molecular Weight	279.252
Flash Point	248.7±31.5 °C
Exact Mass	279.096741
PSA	103.79000
LogP	1.46
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.738
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF8029000

CHEMICAL NAME :: Benzofurazan, 7-(4-methyl-1-piperazinyl)-4-nitro-, 1-oxide

CAS REGISTRY NUMBER :: 58131-57-0

LAST UPDATED :: 199410

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H13-N5-O4

MOLECULAR WEIGHT :: 279.29

WISWESSER LINE NOTATION :: T56 BNONJ BO FNW I- AT6N DNTJ D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 2 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,3735,1975