7218-43-1
7218-43-1 structure
- Name: Propargyl-PEG2-OH
- Chemical Name: 2-(2-prop-2-ynoxyethoxy)ethanol
- CAS Number: 7218-43-1
- Molecular Formula: C7H12O3
- Molecular Weight: 144.168
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-12-28 17:31:13
- Modify Date: 2024-01-08 20:24:57
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Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1].
| Name | 2-(2-prop-2-ynoxyethoxy)ethanol |
|---|---|
| Synonyms |
HUSDTFBXUYBZJD-UHFFFAOYSA
2-[2-(2-Propyn-1-yloxy)ethoxy]ethanol 2-[2-(PROP-2-YNYLOXY)ETHOXY]ETHAN-1-OL Propargyl-PEG3 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanol Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]- propargyl-PEG2-OH Ethanol,2-(2-(2-propynyloxy)ethoxy) 3,6-dioxanon-8-yn-1-ol ethanol, 2-(2-(2-propynyloxy)ethoxy)- 2,6-DIMETHYLCYCLOHEXANOL O-Prop-2-inyl-diaethylenglykol 2-(2-Prop-2-inyloxy-aethoxy)-aethanol 2-(2-prop-2-ynyloxy-ethoxy)-ethanol |
| Description | Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 225.6±20.0 °C at 760 mmHg |
| Molecular Formula | C7H12O3 |
| Molecular Weight | 144.168 |
| Flash Point | 90.3±21.8 °C |
| Exact Mass | 144.078644 |
| PSA | 38.69000 |
| LogP | -0.61 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.453 |
|
~94%
7218-43-1 |
| Literature: Percec, Virgil; Leowanawat, Pawaret; Sun, Hao-Jan; Kulikov, Oleg; Nusbaum, Christopher D.; Tran, Tam M.; Bertin, Annabelle; Wilson, Daniela A.; Peterca, Mihai; Zhang, Shaodong; Kamat, Neha P.; Vargo, Kevin; Moock, Diana; Johnston, Eric D.; Hammer, Daniel A.; Pochan, Darrin J.; Chen, Yingchao; Chabre, Yoann M.; Shiao, Tze C.; Bergeron-Brlek, Milan; Andre, Sabine; Roy, Rene; Gabius, Hans-J.; Heiney, Paul A. Journal of the American Chemical Society, 2013 , vol. 135, # 24 p. 9055 - 9077 |
|
~%
7218-43-1 |
| Literature: Atavin,A.S. et al. Journal of Organic Chemistry USSR (English Translation), 1967 , vol. 3, p. 10 - 12 Zhurnal Organicheskoi Khimii, 1967 , vol. 3, # 1 p. 12 - 15 |
|
~%
7218-43-1 |
| Literature: Reppe et al. Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 65 |
