145916-41-2

145916-41-2 structure

Name: Propargyl-PEG2-Tos
Chemical Name: 2-(prop-2-yn-1-yloxy)ethyl 4-methylbenzenesulfonate
CAS Number: 145916-41-2
Molecular Formula: C₁₂H₁₄O₄S
Molecular Weight: 254.30200
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-12-26 15:16:36
Modify Date: 2024-01-08 09:26:44
Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(prop-2-yn-1-yloxy)ethyl 4-methylbenzenesulfonate
Synonyms	2-(2-propynyloxy)ethanol p-toluenesulfonate 2-(propargyloxy)ethyl p-toluenesulfonate 3-oxohex-5-ynyl tosylate 2-(2-propynyloxy)ethyl tosylate 2-prop-2-ynyloxyethyl p-toluenesulfonate 2-(prop-2-ynyloxy)ethyl p-toluenesulfonate

Description	Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562