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944561-44-8

944561-44-8 structure
944561-44-8 structure
  • Name: Propargyl-PEG2-amine
  • Chemical Name: 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
  • CAS Number: 944561-44-8
  • Molecular Formula: C7H13NO2
  • Molecular Weight: 143.18400
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2017-08-19 11:19:24
  • Modify Date: 2024-01-03 19:05:46
  • Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].

Name 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine
Synonyms 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine
2-(2-(prop-2-ynyloxy)ethoxy)ethanamine
Description Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2].
Related Catalog
Target

Non-cleavable

PEGs

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Changchun Wang, et al. A kind of antibody coupling matter and its construction method containing boron ester units polymer. CN108721642A.

[2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.

Molecular Formula C7H13NO2
Molecular Weight 143.18400
Exact Mass 143.09500
PSA 44.48000
LogP 0.31180
Storage condition 2-8°C
RIDADR 2735.0
Hazard Class 8.0