Name | 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine |
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Synonyms |
2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine
2-(2-(prop-2-ynyloxy)ethoxy)ethanamine |
Description | Propargyl-PEG2-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1][2]. |
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Related Catalog | |
Target |
Non-cleavable PEGs |
In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
References |
[2]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1. |
Molecular Formula | C7H13NO2 |
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Molecular Weight | 143.18400 |
Exact Mass | 143.09500 |
PSA | 44.48000 |
LogP | 0.31180 |
Storage condition | 2-8°C |
RIDADR | 2735.0 |
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Hazard Class | 8.0 |