70678-95-4

70678-95-4 structure

Name: Hydroxy-PEG4-CH2COOH
Chemical Name: 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetic acid
CAS Number: 70678-95-4
Molecular Formula: C₁₀H₂₀O₇
Molecular Weight: 252.26200
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-03-26 13:27:16
Modify Date: 2024-01-13 20:03:28
Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]acetic acid
Synonyms	Carbomethoxytetraethylenglykol 14-hydroxy-3,6,9,12-tetraoxatetradecanoic acid 3,6,9,12-Tetraoxatetradecanoic acid,14-hydroxy

Description	Hydroxy-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Molecular Formula	C₁₀H₂₀O₇
Molecular Weight	252.26200
Exact Mass	252.12100
PSA	94.45000

112-60-7

3926-62-3

70678-95-4

Literature: Chen, Bin; Baumeister, Ute; Pelzl, Gerhard; Das, Malay Kumar; Zeng, Xiangbing; Ungar, Goran; Tschierske, Garsten Journal of the American Chemical Society, 2005 , vol. 127, # 47 p. 16578 - 16591

77303-64-1

~99%

70678-95-4

Literature: Nakatsuji, Yohji; Kawamura, Norio; Okahara, Mitsuo; Matsushima, Kenji Synthesis, 1981 , # 1 p. 42 - 44

112-60-7

79-11-8

~58%

70678-95-4

Literature: Yamaguchi, Kazuo; Kuboniwa, Hitoshi; Murakami, Nobuya; Hirao, Akira; Nakahama, Swiichi; Yamazaki, Noburo Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 4 p. 1097 - 1101

154773-34-9

70678-95-4

Literature: Bostic, Heidi E.; Smith, Matthew D.; Poloukhtine, Andrei A.; Popik, Vladimir V.; Best, Michael D. Chemical Communications, 2012 , vol. 48, # 10 p. 1431 - 1433

112-60-7

70678-95-4

Literature: Nakatsuji, Yohji; Kawamura, Norio; Okahara, Mitsuo; Matsushima, Kenji Synthesis, 1981 , # 1 p. 42 - 44

112-60-7

1068-52-6

70678-95-4

Literature: Matsushima,K. et al. Tetrahedron Letters, 1979 , # 36 p. 3445 - 3448

Precursor 6
112-60-7 3926-62-3 77303-64-1 79-11-8
154773-34-9 1068-52-6
DownStream 0

70678-95-4	2194563-83-0
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