197781-85-4

197781-85-4 structure

Name: Bonducellpin D
Chemical Name: (3bS,3b1R,5aR,6S,6aR,10S,10aS,10bS)-6a,10-dihydroxy-7,7,10a-trimethyl-4-oxo-3b,3b1,5a,6,6a,7,8,9,10,10a,10b,11-dodecahydro-4H-phenanthro[3,2-b:10,1-b'c']difuran-6-yl acetate
CAS Number: 197781-85-4
Molecular Formula: C₂₂H₂₈O₇
Molecular Weight: 404.453
Catalog: Natural product Moss
Create Date: 2017-05-20 16:13:27
Modify Date: 2024-01-09 10:49:53
Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV Mpro and MERS-CoV Mpro, with an Ki of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro[1][2][3].

Name	(3bS,3b1R,5aR,6S,6aR,10S,10aS,10bS)-6a,10-dihydroxy-7,7,10a-trimethyl-4-oxo-3b,3b1,5a,6,6a,7,8,9,10,10a,10b,11-dodecahydro-4H-phenanthro[3,2-b:10,1-b'c']difuran-6-yl acetate
Synonyms	Bonducellpin D 4H-Phenanthro[3,2-b:10,1-b'c']difuran-4-one, 6-(acetyloxy)-3b,5a,6,6a,7,8,9,10,10a,10b,10c,11-dodecahydro-6a,10-dihydroxy-7,7,10a-trimethyl-, (3bS,5aR,6S,6aR,10S,10aS,10bS,10cR)- (3bS,5aR,6S,6aR,10S,10aS,10bS,10cR)-6a,10-Dihydroxy-7,7,10a-trimethyl-4-oxo-3b,5a,6,6a,7,8,9,10,10a,10b,10c,11-dodecahydro-4H-furo[3',2':2,3]phenanthro[10,1-bc]furan-6-yl acetate

Description	Bonducellpin D is a furanoditerpenoid lactone isolated from Caesalpinia minax. Bonducellpin D exhibits broad-spectrum inhibition potential against SARS-CoV Mpro and MERS-CoV Mpro, with an Ki of 467.11 and 284.86 nM, respectively. Bonducellpin D also exhibits moderate anti-cancer activity in vitro[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	Ki: 467.11 nM (SARS-CoV Mpro), 284.86 nM (MERS-CoV Mpro)[1]
References	[1]. Gurung AB, et, al. Unravelling lead antiviral phytochemicals for the inhibition of SARS-CoV-2 M pro enzyme through in silico approach. Life Sci. 2020 Aug 15;255:117831. [2]. Zheng Y, et, al. Caesalminaxins A-L, cassane diterpenoids from the seeds of Caesalpinia minax. J Nat Prod. 2013 Dec 27; 76(12): 2210-8. [3]. Jiang RW, et, al. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Bioorg Med Chem. 2002 Jul;10(7):2161-70.

Hazard Codes	Xi