729610-18-8
729610-18-8 structure
- Name: Calindol hydrochloride
- Chemical Name: (1R)-N-(1H-indol-2-ylmethyl)-1-naphthalen-1-ylethanamine,hydrochloride
- CAS Number: 729610-18-8
- Molecular Formula: C21H21ClN2
- Molecular Weight: 336.85800
- Catalog: Signaling Pathways GPCR/G Protein CaSR
- Create Date: 2017-01-12 06:17:03
- Modify Date: 2024-01-11 17:43:53
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Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].
| Name | (1R)-N-(1H-indol-2-ylmethyl)-1-naphthalen-1-ylethanamine,hydrochloride |
|---|---|
| Synonyms | Calindol Hydrochloride |
| Description | Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 在 2mM Ca2+ 存在的情况下，Calindol 刺激磷脂酰肌醇 (PI) 在表达大鼠或人 CaSR 的细胞中的 EC50 分别为 1.0 μM 或 0.31 μM[2]。 在线肌造影研究中，Calindol (1-10 µM) 抑制 Methoxamine 和 KCl 诱导的预收缩张力，并抑制兔肠系膜动脉中的全细胞电压门控 Ca2+ 通道 (VGCC) 电流[3]。 |
| References |
| Molecular Formula | C21H21ClN2 |
|---|---|
| Molecular Weight | 336.85800 |
| Exact Mass | 336.13900 |
| PSA | 27.82000 |
| LogP | 6.36480 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |