Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Musk ketone
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Musk ketone
Price: ￥118.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Musk ketone
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Musk ketone
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Musk ketone
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

81-14-1

81-14-1 structure

Name: Musk ketone
Chemical Name: musk ketone
CAS Number: 81-14-1
Molecular Formula: C₁₄H₁₈N₂O₅
Molecular Weight: 294.30
Catalog: Flavors and spices Synthetic spice Musk and macrocyclic spices Nitro musk
Create Date: 2018-05-23 08:00:00
Modify Date: 2024-01-02 17:58:03
Musk ketone (MK) is a widely used artificial fragrance. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].

Name	musk ketone
Synonyms	KETONE MOSCHUS Acetophenone, 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitro- (8CI) 4-acetyl-1-tert-butyl-3,5-dimethyl-2-nitro-6-aminobenzene 2-acetyl-5-tert-butyl-4,6-dinitroxylene 3-METHYLCYCLOPENTADECANONE (D,L-MUSCONE) EINECS 201-328-9 1-tert-butyl-3,5-dimethyl-2,6-dinitro-4-acetylbenzene 4'-tert-butyl-2',6'-dimethyl-3',5'-dinitroacetophenone 4-tert-butyl-3,5-dinitro-2,6-dimethyl-acetophenone MOSCHUS 3,5-dinitro-2,6-dimethyl-4-t-butylacetophenone 1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanone Ketone musk 1-(4-tert-butyl-2,6-dimethyl-3,5-dinitrophenyl)ethanon Dinitro-tert-butylxylyl methyl ketone MOSCHUS KETON Ethanone, 1-[4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophenyl]- Musk ketone MFCD00024271 Acetyl-dinitro-butyl-xylene 1-[2,6-Dimethyl-4-(2-methyl-2-propanyl)-3,5-dinitrophenyl]ethanone

Description	Musk ketone (MK) is a widely used artificial fragrance. Musk ketone shows mutagenic and comutagenic effects in Hep G2 cells and induces neural stem cell proliferation and differentiation in cerebral ischemia via activation of the PI3K/Akt signaling pathway. In the brain, musk ketone is neuroprotective against stroke injury through inhibition of cell apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Neurological Disease
References	[1]. Yamagishi T, et al. Identification of musk xylene and musk ketone in freshwater fish collected from the Tama River, Tokyo. Bull Environ Contam Toxicol. 1981 May;26(5):656-62. [2]. Mersch-Sundermann V, et al. Musk ketone enhances benzo(a)pyrene induced mutagenicity in human derived Hep G2 cells. Mutat Res. 2001 Aug 22;495(1-2):89-96. [3]. Zhou Z, et al. Musk Ketone Induces Neural Stem Cell Proliferation and Differentiation in Cerebral Ischemia via Activation of the PI3K/Akt Signaling Pathway. Neuroscience. 2020 May 21;435:1-9.

Density	1.2±0.1 g/cm3
Boiling Point	369.0±42.0 °C at 760 mmHg
Melting Point	135-139 °C(lit.)
Molecular Formula	C₁₄H₁₈N₂O₅
Molecular Weight	294.30
Flash Point	153.2±20.7 °C
Exact Mass	294.121582
PSA	108.71000
LogP	3.86
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.548
Stability	Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
Water Solubility	Insoluble (

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5775841

CHEMICAL NAME :: Ethanone, 1-(4-(1,1-dimethylethyl)-2,6-dimethyl-3,5-dinitrophen yl)-

CAS REGISTRY NUMBER :: 81-14-1

BEILSTEIN REFERENCE NO. :: 2062638

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H18-N2-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,877,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,877,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 26,656,1981

Symbol	GHS08, GHS09
Signal Word	Warning
Hazard Statements	H351-H410
Precautionary Statements	P273-P281-P501
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F: Flammable;Xn: Harmful;
Risk Phrases	R11
Safety Phrases	S16-S36/37
RIDADR	UN1648 3/PG 2
WGK Germany	2
RTECS	KM5775841
Hazard Class	3.0

2040-10-0

~68%

81-14-1

Literature: Safaei-Ghomi, Javad; Bamoniri, Abdolhamid Organic Preparations and Procedures International, 2004 , vol. 36, # 2 p. 188 - 191

2040-10-0

~39%

81-15-2

81-14-1

71850-77-6

Literature: Synthesis, , # 8 p. 1291 - 1293

2040-10-0

~55%

81-14-1

71850-77-6

Literature: Synthesis, , # 8 p. 1291 - 1293

98-19-1

81-14-1

Literature: Organic Preparations and Procedures International, , vol. 36, # 2 p. 188 - 191

Precursor 2
2040-10-0 98-19-1
DownStream 0

81-14-1	541-91-3
89780-06-3	145-39-1
67919-67-9	236391-76-7
83-66-9	81-15-2
88642-03-9	877119-10-3
1158522-08-7	940364-43-2
2137797-33-0	2580236-13-9
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4