25152-20-9

25152-20-9 structure
25152-20-9 structure
  • Name: Thymidine,5'-amino-5'-deoxy-
  • Chemical Name: 5'-amino-5'-deoxythymidine
  • CAS Number: 25152-20-9
  • Molecular Formula: C10H15N3O4
  • Molecular Weight: 241.24
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
  • Create Date: 2018-12-06 15:17:42
  • Modify Date: 2024-01-06 17:07:11
  • 5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name 5'-amino-5'-deoxythymidine
Synonyms 5'-Amino-5'-deoxy-D-thymidine
5'-amino-3'-hydroxythymidine
5'-amino-5'-deoxy-thymidine
5'-deoxy-5'-aminothymidine
5'-deoxy-5'-amino-deoxythymidine
Description 5′-Amino-5′-deoxythymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Density 1.394 g/cm3
Molecular Formula C10H15N3O4
Molecular Weight 241.24
Exact Mass 241.10600
PSA 110.34000
Index of Refraction 1.565
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

~10%

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Literature: Wako Pure Chemical Industries, Ltd. Patent: US2008/64868 A1, 2008 ; Location in patent: Page/Page column 10; 11 ;

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Literature: Tetzlaff, Charles N.; Schwope, Ina; Bleczinski, Colleen F.; Steinberg, Joshua A.; Richert, Clemens Tetrahedron Letters, 1998 , vol. 39, # 24 p. 4215 - 4218

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Literature: Challa, Hemavathi; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481

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Literature: Charles; Arya, Dev P. Journal of Carbohydrate Chemistry, 2005 , vol. 24, # 2 p. 145 - 160

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Literature: Druillennec, Sabine; Meudal, Herve; Roques, Bernard P.; Fournie-Zaluski, Marie-Claude Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 4 p. 627 - 632