Name | imetit dihydrobromide |
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Synonyms |
Imetit dihydrobromide
S-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide |
Description | Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM)[1][2][3]. |
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Related Catalog | |
Target |
H3 Receptor:0.3 nM (Ki) H4 receptor:2.7 nM (Ki) |
In Vivo | Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine[4]. Animal Model: Male Sprague-Dawley rats[4] Dosage: 2.5, 5, 10 mg/kg Administration: i.p. (30 min before Apomorphine) Result: Reduced the licking response induced by Apomorphine. |
References |
Boiling Point | 430.8ºC at 760mmHg |
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Melting Point | 206 - 207 °C |
Molecular Formula | C6H12Br2N4S |
Molecular Weight | 332.05900 |
Flash Point | 214.3ºC |
Exact Mass | 329.91500 |
PSA | 103.85000 |
LogP | 3.29510 |
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P261-P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | 36/37/38 |
Safety Phrases | 26-36 |
RIDADR | NONH for all modes of transport |
HS Code | 2933290090 |
HS Code | 2933290090 |
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Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |