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60-31-1

60-31-1 structure
60-31-1 structure
  • Name: Acetylcholine chloride
  • Chemical Name: acetylcholine chloride
  • CAS Number: 60-31-1
  • Molecular Formula: C7H16ClNO2
  • Molecular Weight: 181.660
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Fluoropyridine
  • Create Date: 2018-07-16 17:51:11
  • Modify Date: 2024-01-04 14:11:56
  • Acetylcholine is a neurotransmitter that can induce the opening of calcium channels. Target: Calcium Channel; nAChR; mAChRAcetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.Acetylcholine chloride, more commonly referred to as just acetylcholine, is a cholinergic neurotransmitter that can induce the opening of calcium channels, as well as act on nicotinic and muscarinic acetylcholine receptors. Acetylcholine plays an important role at many sites in the central nervous system. The compound has been shown to have ophthalmological uses and can be broken down quickly by choliesterases. Studies show that non-neuronal acetylcholine influences many basic cells functions, such as mitosis, cells differentiation, cytoskeletal organization, and cell to cell contact, among other functions [1-3].
Name acetylcholine chloride
Synonyms Acetylcholine chloride
2-Acetoxy-N,N,N-trimethylethanaminium chloride
ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride
chlorure de 2-(acétyloxy)-N,N,N-triméthyléthanaminium
Ovisot
Acecoline
EINECS 200-468-8
MFCD00011698
Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1)
Arterocoline
2-(acetyloxy)-N,N,N-trimethylethanaminium chloride
Acetylcholine chloride,2-(Acetyloxy)-N,N,N-trimethylethanaminiumchloride
2-(Acetyloxy)-N,N,N-trimethylethanaminiumchlorid
Acetylcholinium chloride
Acetylcholine (chloride)
Description Acetylcholine is a neurotransmitter that can induce the opening of calcium channels. Target: Calcium Channel; nAChR; mAChRAcetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.Acetylcholine chloride, more commonly referred to as just acetylcholine, is a cholinergic neurotransmitter that can induce the opening of calcium channels, as well as act on nicotinic and muscarinic acetylcholine receptors. Acetylcholine plays an important role at many sites in the central nervous system. The compound has been shown to have ophthalmological uses and can be broken down quickly by choliesterases. Studies show that non-neuronal acetylcholine influences many basic cells functions, such as mitosis, cells differentiation, cytoskeletal organization, and cell to cell contact, among other functions [1-3].
Related Catalog
References

[1]. Pepeu, G. and P. Blandina, The acetylcholine, GABA, glutamate triangle in the rat forebrain. J Physiol Paris, 1998. 92(5-6): p. 351-5.

[2]. Israel, M. and Y. Dunant, Acetylcholine release and the cholinergic genomic locus. Mol Neurobiol, 1998. 16(1): p. 1-20.

[3]. Lei, X., et al., Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res, 2008. 300(7): p. 335-41.
Melting Point 146-150 °C(lit.)
Molecular Formula C7H16ClNO2
Molecular Weight 181.660
Exact Mass 181.086960
PSA 26.30000
Stability Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FZ9800000
CHEMICAL NAME :
Choline acetate (ester), chloride
CAS REGISTRY NUMBER :
60-31-1
LAST UPDATED :
199701
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C7-H16-N-O2.Cl
MOLECULAR WEIGHT :
181.69
WISWESSER LINE NOTATION :
1VO2K1&1&1 &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15300 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 20(4),32,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 58,337,1936
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,541,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
7700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 170,461,1967
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - stiffness Cardiac - other changes
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 164,346,1932 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3203 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2698 (estimated) No. of Female Employees: 1846 (estimated)
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS FZ9800000
HS Code 29379000
67-48-1 structure

67-48-1

108-24-7 structure

108-24-7

~%

60-31-1 structure

60-31-1

Literature: Nippon Nogei Kagaku Kaishi, , vol. 23, p. 456,458 Chem.Abstr., , p. 2696
67-48-1 structure

67-48-1

75-36-5 structure

75-36-5

~%

60-31-1 structure

60-31-1

Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 232, p. 266 Justus Liebigs Annalen der Chemie, , vol. 142, p. 325
75-50-3 structure

75-50-3

~%

60-31-1 structure

60-31-1

Literature: Bulletin de la Societe Chimique de France, , vol. <4>15, p. 547
67-48-1 structure

67-48-1

64-19-7 structure

64-19-7

~%

60-31-1 structure

60-31-1

Literature: Journal of Organic Chemistry, , vol. 52, # 8 p. 1613 - 1615
852998-99-3 structure

852998-99-3

~%

60-31-1 structure

60-31-1

72254-56-9 structure

72254-56-9

Literature: Canadian Journal of Chemistry, , vol. 88, # 10 p. 1009 - 1016
HS Code 2923900090
Summary 2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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