636-00-0
636-00-0 structure
- Name: 6-HYDROXYDOPAMINE HYDROBROMIDE
- Chemical Name: 6-Hydroxydopamine hydrobromide
- CAS Number: 636-00-0
- Molecular Formula: C8H12BrNO3
- Molecular Weight: 250.090
- Catalog: Biochemical Amino acids and their derivatives Amino alcohol derivative
- Create Date: 2018-03-20 08:00:00
- Modify Date: 2024-01-04 09:58:27
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Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. In vitro: Oxidopamine hydrobromide-induced apoptosis of PC12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed Akt phosphorylation and increased p38 phosphorylation. It is likely that pCPT-cAMP prevented the Oxidopamine hydrobromide-induced apoptosis via activation of the PI3-kinase/Akt pathway without any effect on superoxide generation or mitochondrial membrane depolarization. [1]In vivo the presence of sulfhydryl antioxidants protected against neuronal degeneration in the striatum, which was particularly remarkable in the case of CySH and was attributed to its capacity to remove the H2O2 produced in the autoxidation of Oxidopamine hydrobromide.
| Name | 6-Hydroxydopamine hydrobromide |
|---|---|
| Synonyms |
5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide (1:1)
1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1) 5-(2-aminoethyl)benzene-1,2,4-triol,hydrobromide 5-(2-Aminoethyl)benzene-1,2,4-triol hydrobromide (1:1) EINECS 211-247-0 MFCD00012894 Oxidopamine (hydrobromide) |
| Description | Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. In vitro: Oxidopamine hydrobromide-induced apoptosis of PC12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed Akt phosphorylation and increased p38 phosphorylation. It is likely that pCPT-cAMP prevented the Oxidopamine hydrobromide-induced apoptosis via activation of the PI3-kinase/Akt pathway without any effect on superoxide generation or mitochondrial membrane depolarization. [1]In vivo the presence of sulfhydryl antioxidants protected against neuronal degeneration in the striatum, which was particularly remarkable in the case of CySH and was attributed to its capacity to remove the H2O2 produced in the autoxidation of Oxidopamine hydrobromide. |
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| Related Catalog | |
| References |
| Boiling Point | 406ºC at 760 mmHg |
|---|---|
| Melting Point | 216-220 °C(lit.) |
| Molecular Formula | C8H12BrNO3 |
| Molecular Weight | 250.090 |
| Flash Point | 199.3ºC |
| Exact Mass | 249.000046 |
| PSA | 86.71000 |
| LogP | 1.96300 |
| Appearance | solid | tan to brown |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DC4600000 |
| HS Code | 2922299090 |
| Precursor 0 | |
|---|---|
| DownStream 1 | |
| HS Code | 2922299090 |
|---|---|
| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |