876305-42-9
876305-42-9 structure
- Name: N-Arachidonyl maleimide
- Chemical Name: N-Arachidonyl maleimide,1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione
- CAS Number: 876305-42-9
- Molecular Formula: C24H35NO2
- Molecular Weight: 369.540
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MAGL
- Create Date: 2017-04-16 03:30:33
- Modify Date: 2024-01-08 18:14:21
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N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1].
| Name | N-Arachidonyl maleimide,1-(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraen-1-yl-1H-pyrrole-2,5-dione |
|---|---|
| Synonyms |
1H-Pyrrole-2,5-dione, 1-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraen-1-yl]-
1-[(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraen-1-yl]-1H-pyrrole-2,5-dione 1-[(5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraen-1-yl]-1H-pyrrole-2,5-dione |
| Description | N-Arachidonyl maleimide is a potent, irreversible inhibitor of monoacylglycerol lipase (MAGL) with an IC50 value of 140 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 140 nM (MAGL)[1] |
| In Vitro | N-Arachidonyl maleimide is a putative MAGL inhibitor, which can be used for modulation of the effects of 2-arachidonyl glycerol (2-AG). N-Arachidonyl maleimide increases endogenous levels of 2-AG in the brain. N-Arachidonyl maleimide prevents cerebellar membrane-mediated degradation of 2-AG at a relatively low concentration (IC50, 140 nM)[1]. |
| In Vivo | When combined with a 1 mg/kg dose of N-Arachidonyl maleimide, 2-AG (1, 3, and 10 mg/kg) produces significant and dose-dependent hypothermia, inhibition of locomotor activity, antinociception, and catalepsy[1]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 492.9±34.0 °C at 760 mmHg |
| Molecular Formula | C24H35NO2 |
| Molecular Weight | 369.540 |
| Flash Point | 185.2±18.0 °C |
| Exact Mass | 369.266785 |
| PSA | 37.38000 |
| LogP | 7.89 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.524 |
