1989-52-2
1989-52-2 structure
- Name: Cholesterol myristate
- Chemical Name: cholesteryl myristate
- CAS Number: 1989-52-2
- Molecular Formula: C41H72O2
- Molecular Weight: 597.00900
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-04-24 08:00:00
- Modify Date: 2024-01-02 23:31:07
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Cholesterol myristate is a natural steroid present in traditional Chinese medicine.
| Name | cholesteryl myristate |
|---|---|
| Synonyms |
Cholesterol=tetradecanoate
CHOLESTERYL TETRADODEDECANOATE EINECS 217-867-8 Cholesteryl myristate Cholest-5-en-3-yl myristate Cholesterol Myristate Cholestryl myristate MFCD00014256 Myristic Acid Cholesterol Ester O-myristoyl-cholesterol cholesteryl tetradecanoate Cholestryl myristic acid Myristinsaeure-cholesterylester |
| Description | Cholesterol myristate is a natural steroid present in traditional Chinese medicine. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1]. |
| Cell Assay | MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1]. |
| References |
| Density | 0.95 g/cm3 |
|---|---|
| Boiling Point | 630.7ºC at 760 mmHg |
| Melting Point | 84 °C |
| Molecular Formula | C41H72O2 |
| Molecular Weight | 597.00900 |
| Flash Point | 334.8ºC |
| Exact Mass | 596.55300 |
| PSA | 26.30000 |
| LogP | 12.64070 |
| Vapour Pressure | 8.15E-16mmHg at 25°C |
| Index of Refraction | 1.506 |
| Storage condition | −20°C |
