115-33-3
115-33-3 structure
- Name: Oxyphenisatin acetate
- Chemical Name: [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate
- CAS Number: 115-33-3
- Molecular Formula: C24H19NO5
- Molecular Weight: 401.41100
- Catalog: API Digestive system medication Laxative antidiarrheal
- Create Date: 2018-07-08 09:38:37
- Modify Date: 2024-01-11 18:48:57
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Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative.
| Name | [4-[3-(4-acetyloxyphenyl)-2-oxo-1H-indol-3-yl]phenyl] acetate |
|---|---|
| Synonyms |
3,3-bis-(4-acetoxy-phenyl)-indolin-2-one
Izafenin 3,3-bis[4-(acetyloxy)phenyl]-1,3-dihydro-2H-indol-2-one Darmoletten Diphesatine Acetalax Contax Promassolax 3,3-bis(4-acetoxyphenyl)oxindole Brocatine Isaphenin OXYPHENISATIN ACETATE EINECS 204-083-6 Diphesatin 3,3-Bis-(4-acetoxy-phenyl)-indolin-2-on oxyphenisatine di(acetate) |
| Description | Oxyphenisatin acetate, the pro-drug of oxyphenisatin, is used to be a laxative. |
|---|---|
| Related Catalog | |
| In Vitro | Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction[1]. |
| In Vivo | Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model[1]. |
| Animal Admin | Assessment in several other tumor models demonstrates tolerability with oxyphenisatin acetate at 300 mg/kg given once daily or 200 mg/kg given twice daily. For the MCF-7 study treatments are administered on an exact body weight basis using dose volumes of 1-2 mL/kg body weight. The vehicle control receives 100% DMSO. The treated group receives 300 mg/kg oxyphenisatin acetate once daily for a total of 10 days, followed by a 3 day rest and an additional 6 days of dosing. The dose solutions are prepared in 100% DMSO, aliquoted and stored frozen until used. The mice are monitored for a total of 52 days with treatment initiation occurring on day 27 posttumor implantation[1]. |
| References |
| Density | 1.282 g/cm3 |
|---|---|
| Boiling Point | 566.5ºC at 760 mmHg |
| Melting Point | 244℃ |
| Molecular Formula | C24H19NO5 |
| Molecular Weight | 401.41100 |
| Flash Point | 296.4ºC |
| Exact Mass | 401.12600 |
| PSA | 81.70000 |
| LogP | 3.96170 |
| Vapour Pressure | 7.5E-13mmHg at 25°C |
| Index of Refraction | 1.611 |
| Storage condition | 2-8℃ |
| HS Code | 2933790090 |
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115-33-3 |
| Literature: Nakazawa; Matsuura Yakugaku Zasshi, 1954 , vol. 74, p. 69 Chem.Abstr., 1955 , p. 1631 |
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115-33-3 |
| Literature: Inagaki; Nakato Yakugaku Zasshi, 1933 , vol. 53, p. 719,722; dtsch. Ref. S. 134 Chem.Abstr., 1934 , p. 2003 |
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115-33-3 |
| Literature: Hoffmann-La Roche and Co. Patent: DE406210 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 1412 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE447539 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1693 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE482435 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2519 |
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115-33-3 |
| Literature: Hoffmann-La Roche and Co. Patent: DE406210 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 1412 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE447539 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1693 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE482435 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2519 |
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115-33-3 |
| Literature: Hoffmann-La Roche and Co. Patent: DE406210 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 14, p. 1412 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE447539 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 15, p. 1693 Full Text Show Details Hoffmann-La Roche and Co. Patent: DE482435 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 2519 |
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115-33-3 |
| Literature: Inagaki Yakugaku Zasshi, 1933 , vol. 53, p. 686,696;dtsch.Ref.S.133 Chem. Zentralbl., 1933 , vol. 104, # II p. 2133 |
| HS Code | 2933790090 |
|---|---|
| Summary | 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0% |