14325-03-2
14325-03-2 structure
- Name: Cobalt protoporphyrin IX
- Chemical Name: Cobalt, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))
- CAS Number: 14325-03-2
- Molecular Formula: C34H32CoN4O4
- Molecular Weight: 619.58
- Create Date: 2018-04-02 08:00:00
- Modify Date: 2024-01-02 17:29:34
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Cobalt protoporphyrin IX is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV)[1].
| Name | Cobalt, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-)) |
|---|---|
| Synonyms |
Cobalt(II) protoporphyrin IX
Co(II) protoporphyrin cobaltiprotoporphyrin protoporphyrinkobalt(II) Co(porphyrin IX) protoporphyrin IX-Co Cobalt [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoic acid] Cobalt protoporphyrin IX COBALTPROTOPORPHYRIN |
| Description | Cobalt protoporphyrin IX is a potent and specific heme oxygenase-1 (HO-1) inducer. Cobalt protoporphyrin IX exhibits broad-spectrum antiviral activities against Influenza A virus (IAV)[1]. |
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| Related Catalog | |
| In Vitro | Cobalt protoporphyrin IX (72 h) 对 MDCK 细胞和 RAW264.7 细胞的最大无毒浓度 (TC0) 均为 3.13 μM[1]。 Cobalt protoporphyrin IX (2 μM; 0-24 h) 在 MDCK 细胞和 RAW264.7 细胞中以时间依赖的方式增加 HO-1 细胞内蛋白水平[1]。 Cobalt protoporphyrin IX 对 Empty Cell A/FortMonmouth /1/1947、A/TianjinJinnan /15/2009、A/Wuhan /359/1995、A/FujianTongan /196/2009 和 BY/FujianXinluo /54/2006 流感病毒的 IC50分别为 0.40 ± 0.16、0.42 ± 0.15、0.46 ± 0.19、0.34 ± 0.05 和 0.64 ± 0.30 μM[1]。 Cobalt protoporphyrin IX (0.25-2 μM; 18 or 24 h) 通过增强 IFN 反应抑制 IAV 复制，抗 IAV 活性不依赖于 HO-1 的催化功能[1]。 Cobalt protoporphyrin IX (2 μM; 0-6 h) 诱导 HO-1 抗 IAV 活性可能依赖于 IRF3 磷酸化和易位，以增强抗病毒 IFN 应答[1]。 Western Blot Analysis[1] Cell Line: MDCK cells and RAW264.7 cells Concentration: 2 μM Incubation Time: 0, 3, 6, 12 and 24 h Result: Significantly increased the intracellular protein levels of HO-1 in a time-dependent manner in MDCK cells and RAW264.7 cells. Real Time qPCR[1] Cell Line: RAW264.7 cells were infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI) Concentration: 0.25, 0.5, 1 and 2 μM Incubation Time: 18 h Result: Enhanced mRNA expressions of IFN-α/β, as well as protein expressions of some ISGs, such as IFN-inducible transmembrane protein 3 (IFITM3), double-stranded RNA-dependent protein kinase (PKR) and 2′-5′-oligoadenylate synthetase 1 (OAS1), in a dose-dependent manner. Western Blot Analysis[1] Cell Line: RAW264.7 cells or RAW264.7 cells infected with IAV A/Fort Monmouth/1/1947 (0.2 MOI) Concentration: 2 μM Incubation Time: 0, 2, 4 and 6 h Result: Increased protein levels of IRF3 and p-IRF3. Promoted the cytoplasmic protein levels of IRF3 and p-IRF3 in RAW264.7 cells following the enhancement of HO-1 protein expression after 6 h. Induced nuclear IRF3 and nuclear p-IRF3 accumulation within 6 h of treatment. |
| References |
| Boiling Point | 1122ºC at 760mmHg |
|---|---|
| Molecular Formula | C34H32CoN4O4 |
| Molecular Weight | 619.58 |
| Flash Point | 632.4ºC |
| Exact Mass | 619.17600 |
| PSA | 94.32000 |
| LogP | 2.32480 |
| Vapour Pressure | 0mmHg at 25°C |
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14325-03-2 |
| Literature: Berezin, B. D.; Volkova, N. I. Russian Journal of Inorganic Chemistry (Translation of Zhurnal Neorganicheskoi Khimii), 1979 , vol. 24, p. 1197 - 1199 Zhurnal Neorganicheskoi Khimii, 1979 , vol. 24, p. 2162 - 2165 |
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14325-03-2 |
| Literature: Berezin, B. D.; Volkova, N. I. Russian Journal of Inorganic Chemistry (Translation of Zhurnal Neorganicheskoi Khimii), 1979 , vol. 24, p. 1197 - 1199 Zhurnal Neorganicheskoi Khimii, 1979 , vol. 24, p. 2162 - 2165 |
