916440-85-2
916440-85-2 structure
- Name: 7BIO
- Chemical Name: 2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro
- CAS Number: 916440-85-2
- Molecular Formula: C16H10BrN3O2
- Molecular Weight: 356.17400
- Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
- Create Date: 2017-12-24 08:49:04
- Modify Date: 2024-01-12 09:24:05
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7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice[1].
| Name | 2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro |
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| Description | 7BIO (7-Bromoindirubin-3-Oxime) is the derivate of indirubin. 7BIO (7-Bromoindirubin-3-Oxime) has inhibitory effects against cyclin-dependent kinase-5 (CDK5) and glycogen synthase kinase-3β (GSK3β). 7BIO (7-Bromoindirubin-3-Oxime) inhibits Aβ oligomer-induced neuroinflammation, synaptic impairments, tau hyper-phosphorylation, activation of astrocytes and microglia, and attenuates Aβ oligomer-induced cognitive impairments in mice[1]. |
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| Related Catalog | |
| Target |
CDK5 GSK3β |
| In Vitro | 7BIO (1 and 10 μM; 24 hours) has neuroprotective effects and can prevent, but cannot rescue Aβ1−42 oligomer-induced cell death in SH-SY5Y cells[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 1 and 10 μM Incubation Time: 24 hours Result: Inhibit Aβ oligomer-induced neuronal death. 7BIO prevented, but did not rescue Aβ1−42 oligomer-induced cell death in SH-SY5Y cells. |
| In Vivo | 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) significantly attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice[1]. 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) decreases Aβ oligomer-induced increase of TNF-α and IL-6 production in the brain and the expression of synapsin-1 and PSD-95 in the hippocampal region of mice[1]. 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) attenuates Aβ oligomer-induced increase expression of pTau, activation of microglia and astrogliosis in the brain of mice[1]. 7Bio (2.3, 7.0, and 23.3 μg/kg; bilateral ventricle injection) prevents decreased expression of pSer9-GSK3β and has no significant effects on the Tau protein level[1]. Animal Model: 8 weeks mice (30 g)[1] Dosage: 2.3, 7.0, and 23.3 μg/kg Administration: bilateral ventricle injection Result: Attenuates Aβ oligomer-induced impairment of recognition, spatial learning and memory in mice. |
| References |
| Density | 1.80±0.1 g/cm3 (20 °C, 760 mmHg) |
|---|---|
| Boiling Point | 565.5±50.0 °C (760 mmHg) |
| Molecular Formula | C16H10BrN3O2 |
| Molecular Weight | 356.17400 |
| Exact Mass | 354.99600 |
| PSA | 73.72000 |
| LogP | 3.69230 |