651042-83-0

651042-83-0 structure

Name: m-PEG8-thiol
Chemical Name: 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol
CAS Number: 651042-83-0
Molecular Formula: C₁₇H₃₆O₈S
Molecular Weight: 400.52800
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-12-29 10:27:36
Modify Date: 2024-01-04 18:15:20
m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanethiol
Synonyms	2,5,8,11,14,17,20,23-octaoxapentacosane-25-thiol

Description	m-PEG8-thiol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562