- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Tr-PEG2-OH
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Huang
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Tr-PEG3
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: Tr-PEG3
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
105589-77-3
105589-77-3 structure
- Name: Tr-PEG2-OH
- Chemical Name: 2-(2-trityloxyethoxy)ethanol
- CAS Number: 105589-77-3
- Molecular Formula: C23H24O3
- Molecular Weight: 348.43500
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2016-01-06 21:37:22
- Modify Date: 2024-01-14 09:15:39
-
Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
| Name | 2-(2-trityloxyethoxy)ethanol |
|---|---|
| Synonyms |
diethylene glycol monotrityl ether
diethylene glycol monotritylate 7,7,7-triphenyl-2,5-dioxaheptan-1-ol monotritylated diethylene glycol 7,7,7-Triphenyl-3,6-dioxaheptanol |
| Description | Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
| Molecular Formula | C23H24O3 |
|---|---|
| Molecular Weight | 348.43500 |
| Exact Mass | 348.17300 |
| PSA | 38.69000 |
| LogP | 4.00400 |
| Hazard Codes | Xi |
|---|
|
~82%
105589-77-3 |
| Literature: Gothard, Chris M.; Grzybowski, Bartosz A. Synthesis, 2012 , vol. 44, # 5 p. 717 - 722 |
|
~%
105589-77-3 |
| Literature: Fordyce; Lovell; Hibbert Journal of the American Chemical Society, 1939 , vol. 61, p. 1905,1908 |
|
~%
105589-77-3 |
| Literature: Altenburger, Jean-Michel; Lebeau, Luc; Mioskowski, Charles; Schirlin, Daniel Helvetica Chimica Acta, 1992 , vol. 75, # 8 p. 2538 - 2544 |
|
~%
105589-77-3 |
| Literature: Komiotis; Currie; LeBreton; Venton Synthetic Communications, 1993 , vol. 23, # 4 p. 531 - 534 |
