116064-77-8

116064-77-8 structure

Name: Dehydromiltirone
Chemical Name: 8,8-dimethyl-2-propan-2-yl-7H-phenanthrene-3,4-dione
CAS Number: 116064-77-8
Molecular Formula: C₁₉H₂₀O₂
Molecular Weight: 280.36100
Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
Create Date: 2018-09-11 15:59:27
Modify Date: 2024-01-07 08:29:57
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2].

Name	8,8-dimethyl-2-propan-2-yl-7H-phenanthrene-3,4-dione
Synonyms	dehydromiltirone 2-isopropyl-8,8-dimethyl-7.8-dihydrophenanthrene-3,4-dione 1,2-didehydromiltirone

Description	Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
In Vitro	Dehydromiltirone (100 μg/mL; 24 h) 抑制 Kupffer 细胞中的 p38 和 NF-κB 信号[1]。 Dehydromiltirone 抑制破骨细胞相关基因的表达，包括 NFATc1、CTSK、c-Fos、Acp5 和 MMP9；以及MAPK信号通路的 P38、ERK 和 JNK 的磷酸化；以及 NF-κB 信号通路中 IκB-α 的降解。Dehydromiltirone 通过降低相关基因的表达来发挥抗破骨细胞生成作用，最终在体外抑制骨吸收[2]。 Western Blot Analysis[1] Cell Line: Kupffer cells Concentration: 100 μg/mL Incubation Time: For 24 h Result: Significantly decreased p38 and p-p38 levels, NF-κBp65, IκB, and c-fos protein levels.
In Vivo	Dehydromiltirone (50-200 mg/kg，口服；每天；连续五天) 保护肝脏免受 CCl4 诱导的损伤。Dehydromiltirone 可减少促炎细胞因子 TNF-α、IL-1 和 IL-6 的增加，表明它具有减轻肝脏炎症的作用[1]。 Animal Model: Rat model of acute liver injury[1] Dosage: 50 mg/kg, 100 mg/kg, and 200 mg/kg Administration: p.o.; daily; for five consecutive days Result: Protected liver from CCl4-induced damage.
References	[1]. Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52(10):1278-85. [2]. Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693.

Density	1.116g/cm3
Boiling Point	423.8ºC at 760mmHg
Molecular Formula	C₁₉H₂₀O₂
Molecular Weight	280.36100
Flash Point	180.5ºC
Exact Mass	280.14600
PSA	34.14000
LogP	4.18590
Vapour Pressure	2.17E-07mmHg at 25°C
Index of Refraction	1.57

Precursor 7
88-69-7 2944-47-0 22009-41-2 39863-61-1
126979-88-2 153661-62-2 195001-73-1
DownStream 0

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13463-67-7	1333-86-4