809234-33-1

809234-33-1 structure

Name: 4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one
Chemical Name: 4-(chloromethyl)-5,7-dihydroxychromen-2-one
CAS Number: 809234-33-1
Molecular Formula: C₁₀H₇ClO₄
Molecular Weight: 226.61
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2016-11-20 08:56:09
Modify Date: 2024-01-09 18:54:19
DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells[1].

Name	4-(chloromethyl)-5,7-dihydroxychromen-2-one
Synonyms	2H-1-Benzopyran-2-one,4-(chloromethyl)-5,7-dihydroxy 4-(chloromethyl)-5,7-dihydroxy-2H-chromen-2-one 4-chloromethyl-5,7-dihydroxycoumarin 4-(chloromethyl)-5,7-dihydroxy-2H-1-benzopyran-2-one 4-chloromethyl-5-hydroxyumbelliferone

Description	DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	DNA polymerase[1]
In Vivo	DNA polymerase-IN-1 (compound 2d)
References	[1]. Bruna-Haupt EF, et al. Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents. ACS Omega. 2023 Jul 13;8(29):26479-26496.

HS Code	2932209090

108-73-6

638-07-3

~96%

809234-33-1

Literature: Karami, Bahador; Kiani, Mahtab Journal of the Chinese Chemical Society, 2014 , vol. 61, # 2 p. 213 - 216

108-73-6

32807-28-6

~94%

809234-33-1

Literature: Sharghi, Hashem; Jokar, Mahboubeh Heterocycles, 2007 , vol. 71, # 12 p. 2721 - 2733

108-73-6

809234-33-1

Literature: Karami, Bahador; Khodabakhshi, Saeed; Eskandari, Khalil Chemical Papers, 2013 , vol. 67, # 11 p. 1474 - 1478

Precursor 3
108-73-6 638-07-3 32807-28-6
DownStream 0

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%